Simultaneous Determination of Cyclosporine A, Tacrolimus, Sirolimus, and Everolimus in Whole-Blood Samples by LC-MSMS
Joint Authors
Kizilgun, Murat
Karapirli, Mustafa
Gulcan Kurt, Yasemin
Gul, Husamettin
Kunak, Zeki Ilker
Cayci, Tuncer
Yesilyurt, Ozgur
Yaman, Halil
Aydin, Ibrahim
Seyrek, Melik
Cakir, Erdinc
Akgul, Emin Ozgur
Yaren, Hakan
Macit, Enis
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Objectives.
Cyclosporine A (CyA), tacrolimus (TRL), sirolimus (SIR), and everolimus (RAD) are immunosuppressive drugs frequently used in organ transplantation.
Our aim was to confirm a robust sensitive and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for determination of CyA, TRL, SIR, and RAD in whole-blood samples.
Materials and Methods.
We used an integrated online solid-phase extraction-LC-MS/MS system and atmospheric pressure ionization tandem mass spectrometry (API-MS/MS) in the multiple reaction monitoring (MRM) detection mode.
CyA, TRL, SIR, and RAD were simultaneously analyzed in whole blood treated with precipitation reagent taken from transplant patients.
Results.
System performance parameters were suitable for using this method as a high-throughput technique in clinical practice.
The high concentration of one analyte in the sample did not affect the concentration of other analytes.
Total analytical time was 2.5 min, and retention times of all analytes were shorter than 2 minutes.
Conclusion.
This LC-MS/MS method can be preferable for therapeutic drug monitoring of these immunosuppressive drugs (CyA, TRL, SRL, and RAD) in whole blood.
Sample preparation was too short and simple in this method, and it permits robust, rapid, sensitive, selective, and simultaneous determination of these drugs.
American Psychological Association (APA)
Karapirli, Mustafa& Kizilgun, Murat& Yesilyurt, Ozgur& Gul, Husamettin& Kunak, Zeki Ilker& Akgul, Emin Ozgur…[et al.]. 2012. Simultaneous Determination of Cyclosporine A, Tacrolimus, Sirolimus, and Everolimus in Whole-Blood Samples by LC-MSMS. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-481638
Modern Language Association (MLA)
Karapirli, Mustafa…[et al.]. Simultaneous Determination of Cyclosporine A, Tacrolimus, Sirolimus, and Everolimus in Whole-Blood Samples by LC-MSMS. The Scientific World Journal No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-481638
American Medical Association (AMA)
Karapirli, Mustafa& Kizilgun, Murat& Yesilyurt, Ozgur& Gul, Husamettin& Kunak, Zeki Ilker& Akgul, Emin Ozgur…[et al.]. Simultaneous Determination of Cyclosporine A, Tacrolimus, Sirolimus, and Everolimus in Whole-Blood Samples by LC-MSMS. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-481638
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481638