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Use of Antimony in the Treatment of Leishmaniasis : Current Status and Future Directions
Joint Authors
Sen, Pradip
Roy, Syamal
Haldar, Arun Kumar
Source
Molecular Biology International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-08
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
In the recent past the standard treatment of kala-azar involved the use of pentavalent antimonials Sb(V).
Because of progressive rise in treatment failure to Sb(V) was limited its use in the treatment program in the Indian subcontinent.
Until now the mechanism of action of Sb(V) is not very clear.
Recent studies indicated that both parasite and hosts contribute to the antimony efflux mechanism.
Interestingly, antimonials show strong immunostimulatory abilities as evident from the upregulation of transplantation antigens and enhanced T cell stimulating ability of normal antigen presenting cells when treated with Sb(V) in vitro.
Recently, it has been shown that some of the peroxovanadium compounds have Sb(V)-resistance modifying ability in experimental infection with Sb(V) resistant Leishmania donovani isolates in murine model.
Thus, vanadium compounds may be used in combination with Sb(V) in the treatment of Sb(V) resistance cases of kala-azar.
American Psychological Association (APA)
Haldar, Arun Kumar& Sen, Pradip& Roy, Syamal. 2011. Use of Antimony in the Treatment of Leishmaniasis : Current Status and Future Directions. Molecular Biology International،Vol. 2011, no. 2011, pp.1-23.
https://search.emarefa.net/detail/BIM-481639
Modern Language Association (MLA)
Haldar, Arun Kumar…[et al.]. Use of Antimony in the Treatment of Leishmaniasis : Current Status and Future Directions. Molecular Biology International No. 2011 (2011), pp.1-23.
https://search.emarefa.net/detail/BIM-481639
American Medical Association (AMA)
Haldar, Arun Kumar& Sen, Pradip& Roy, Syamal. Use of Antimony in the Treatment of Leishmaniasis : Current Status and Future Directions. Molecular Biology International. 2011. Vol. 2011, no. 2011, pp.1-23.
https://search.emarefa.net/detail/BIM-481639
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481639