Comparison of Clinical Efficacy of Intravenous Acetaminophen with Intravenous Morphine in Acute Renal Colic : A Randomized, Double-Blind, Controlled Trial
Joint Authors
Feli, Maryam
Khavanin, Ali
Barzegari, Hassan
Forouzan, Arash
Asgari Darian, Ali
Masoumi, Kambiz
Source
Emergency Medicine International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-13
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The aim of this study was to compare the clinical efficacy of intravenous acetaminophen with intravenous morphine in acute renal colic pain management.
In this double-blind controlled trial, patients aged 18–55 years, diagnosed with acute renal colic, who met the inclusion and exclusion criteria, were randomized into two groups.
First, using the visual analogue scale (VAS), intensity of pain was assessed in both groups.
Then, one gram of intravenous acetaminophen or 0.1 mg/kg morphine was infused in 100 mL normal saline to either acetaminophen or morphine group.
Intensity of pain was reassessed in 15, 30, 45, and 60 minutes according to VAS criteria.
Finally, data from 108 patients were analyzed, 54 patients in each group.
No significant difference was observed between the two groups in regard to sex (P=0.13), mean age (P=0.54), and baseline visual analogue score (P=0.21).
A repeated measure analysis of variance revealed that the difference between the two treatments was significant (P=0.0001).
The VAS reduction at primary endpoint (30 min after drug administration) was significantly higher in the acetaminophen group than in the morphine group (P=0.0001).
This study demonstrated that intravenous acetaminophen could be more effective than intravenous morphine in acute renal colic patients’ pain relief.
American Psychological Association (APA)
Masoumi, Kambiz& Forouzan, Arash& Asgari Darian, Ali& Feli, Maryam& Barzegari, Hassan& Khavanin, Ali. 2014. Comparison of Clinical Efficacy of Intravenous Acetaminophen with Intravenous Morphine in Acute Renal Colic : A Randomized, Double-Blind, Controlled Trial. Emergency Medicine International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-481646
Modern Language Association (MLA)
Masoumi, Kambiz…[et al.]. Comparison of Clinical Efficacy of Intravenous Acetaminophen with Intravenous Morphine in Acute Renal Colic : A Randomized, Double-Blind, Controlled Trial. Emergency Medicine International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-481646
American Medical Association (AMA)
Masoumi, Kambiz& Forouzan, Arash& Asgari Darian, Ali& Feli, Maryam& Barzegari, Hassan& Khavanin, Ali. Comparison of Clinical Efficacy of Intravenous Acetaminophen with Intravenous Morphine in Acute Renal Colic : A Randomized, Double-Blind, Controlled Trial. Emergency Medicine International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-481646
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481646