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The Influence of Ionizing Radiation, Temperature, and Light on Eplerenone in the Solid State
Joint Authors
Ćwiertnia, Barbara
Dettlaff, Katarzyna
Jelińska, Anna
Kycler, Witold
Garbacki, Piotr
Dołhań, Agnieszka
Ogrodowczyk, Magdalena
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Eplerenone was subjected to the influence of ionizing radiation in the form of a high-energy electron beam (25–400 kGy), high temperature (90°C RH 0% and 60°C RH 76.4%), and light (6 mln lux h).
An HPLC method was used to determine the content of eplerenone and to establish the impurity profile of all samples.
As eplerenone was found to be a compound of great resistance to the above stress factors with the exception of high doses of ionizing radiation (≥200 kGy) when its degradation was above 1%, it is possible to sterilize eplerenone by radiation method with the standard dose of 25 kGy.
Based on the analysis of impurities and degradation products, the mechanism of radiodegradation was demonstrated to differ from the mechanisms of photo- and thermodegradation.
The observation that the DSC curves for the nondegraded and degraded samples of eplerenone were significantly different only under exposure to the electron beam confirmed the applicability of DSC for studies of radiolytic degradation of eplerenone.
American Psychological Association (APA)
Dettlaff, Katarzyna& Ogrodowczyk, Magdalena& Kycler, Witold& Dołhań, Agnieszka& Ćwiertnia, Barbara& Garbacki, Piotr…[et al.]. 2014. The Influence of Ionizing Radiation, Temperature, and Light on Eplerenone in the Solid State. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-481654
Modern Language Association (MLA)
Dettlaff, Katarzyna…[et al.]. The Influence of Ionizing Radiation, Temperature, and Light on Eplerenone in the Solid State. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-481654
American Medical Association (AMA)
Dettlaff, Katarzyna& Ogrodowczyk, Magdalena& Kycler, Witold& Dołhań, Agnieszka& Ćwiertnia, Barbara& Garbacki, Piotr…[et al.]. The Influence of Ionizing Radiation, Temperature, and Light on Eplerenone in the Solid State. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-481654
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481654