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Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males : A Pilot Study
Joint Authors
Ambiye, Vijay R.
Langade, Deepak
Aptikar, Pradnya
Dongre, Atul
Kulkarni, Madhura
Dongre, Swati
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Ashwagandha (Withania somnifera) has been described in traditional Indian Ayurvedic medicine as an aphrodisiac that can be used to treat male sexual dysfunction and infertility.
This pilot study was conducted to evaluate the spermatogenic activity of Ashwagandha root extract in oligospermic patients.
Forty-six male patients with oligospermia (sperm count < 20 million/mL semen) were enrolled and randomized either to treatment (n=21) with a full-spectrum root extract of Ashwagandha (675 mg/d in three doses for 90 days) or to placebo (n=25) in the same protocol.
Semen parameters and serum hormone levels were estimated at the end of 90-day treatment.
There was a 167% increase in sperm count (9.59 ± 4.37 × 106/mL to 25.61 ± 8.6 × 106/mL; P<0.0001), 53% increase in semen volume (1.74 ± 0.58 mL to 2.76 ± 0.60 mL; P<0.0001), and 57% increase in sperm motility (18.62 ± 6.11% to 29.19 ± 6.31%; P<0.0001) on day 90 from baseline.
The improvement in these parameters was minimal in the placebo-treated group.
Furthermore, a significantly greater improvement and regulation were observed in serum hormone levels with the Ashwagandha treatment as compared to the placebo.
The present study adds to the evidence on the therapeutic value of Ashwagandha (Withania somnifera), as attributed in Ayurveda for the treatment of oligospermia leading to infertility.
American Psychological Association (APA)
Ambiye, Vijay R.& Langade, Deepak& Dongre, Swati& Aptikar, Pradnya& Kulkarni, Madhura& Dongre, Atul. 2013. Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males : A Pilot Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-481664
Modern Language Association (MLA)
Ambiye, Vijay R.…[et al.]. Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males : A Pilot Study. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-481664
American Medical Association (AMA)
Ambiye, Vijay R.& Langade, Deepak& Dongre, Swati& Aptikar, Pradnya& Kulkarni, Madhura& Dongre, Atul. Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males : A Pilot Study. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-481664
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481664