Poly(hydroxyalkanoates)-Based Polymeric Nanoparticles for Drug Delivery
Joint Authors
Errico, Cesare
Chiellini, Federica
Chiellini, Emo
Bartoli, Cristina
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-09-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Poly (hydroxyalkanoates) (PHAs) have recently attracted a great deal of academic and industrial interest for their biodegradability and biocompatibility making them suitable for environmental and biomedical applications.
Poly(3-hydroxybutyrate-) (PHB-) and Poly(DL-lactide-co-glycolide) (PLGA-) based nanoparticles were prepared using the dialysis method as yet unreported for the preparation of nanoparticles based on PHB.
Processing conditions were varied in order to evaluate their influence on morphology, drug encapsulation, and size of nanoparticles.
The relevant results obtained give a theoretical understanding of the phenomenon occurring during colloidal formation.
The adopted procedure allows for a relatively small diameter and homogeneity in size distribution of the PHB nanoparticles to be obtained compared to other methods like the one based on solvent evaporation which leads to particles on microscale.
The biocompatibility of PHB and relative nanoparticles was investigated and both exhibited very good cytocompatibility.
American Psychological Association (APA)
Errico, Cesare& Bartoli, Cristina& Chiellini, Federica& Chiellini, Emo. 2009. Poly(hydroxyalkanoates)-Based Polymeric Nanoparticles for Drug Delivery. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-481693
Modern Language Association (MLA)
Errico, Cesare…[et al.]. Poly(hydroxyalkanoates)-Based Polymeric Nanoparticles for Drug Delivery. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-10.
https://search.emarefa.net/detail/BIM-481693
American Medical Association (AMA)
Errico, Cesare& Bartoli, Cristina& Chiellini, Federica& Chiellini, Emo. Poly(hydroxyalkanoates)-Based Polymeric Nanoparticles for Drug Delivery. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-481693
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481693