Investigation of Antidiabetic, Antihyperlipidemic, and In Vivo Antioxidant Properties of Sphaeranthus indicus Linn. in Type 1 Diabetic Rats : An Identification of Possible Biomarkers
Joint Authors
Dharman, J.
Uma Maheswari, M.
Ravi, T. K.
Asokkumar, K.
Rajasekaran, A.
Subramaniam, Saravanan
Sivashanmugam, A. T.
Ramachandran, S.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The present investigation was aimed to study the antidiabetic, antihyperlipidemic, and in vivo antioxidant properties of the root of Sphaeranthus indicus Linn.
in streptozotocin- (STZ-) induced type 1 diabetic rats.
Administration of ethanolic extract of Sphaeranthus indicus root (EESIR) 100 and 200 mg/kg to the STZ-induced diabetic rats showed significant (P<.01) reduction in blood glucose and increase in body weight compared to diabetic control rats.
Both the doses of EESIR-treated diabetic rats showed significant (P<.01) alteration in elevated lipid profile levels than diabetic control rats.
The EESIR treatment in diabetic rats produced significant increase in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and decrease in thiobarbituric acid reactive substances (TBARS) levels than diabetic control rats.
Administration of EESIR 200 mg/kg produced significant (P<.01) higher antioxidant activity than EESIR 100 mg/kg.
The high performance liquid chromatography (HPLC) analysis of EESIR revealed the presence of biomarkers gallic acid and quercetin.
In conclusion, EESIR possess antidiabetic, antihyperlipidemic, and in vivo antioxidant activity in type 1 diabetic rats.
Its antioxidant and lipid lowering effect will help to prevent diabetic complications, and these actions are possibly due to presence of above biomarkers.
American Psychological Association (APA)
Ramachandran, S.& Asokkumar, K.& Uma Maheswari, M.& Ravi, T. K.& Sivashanmugam, A. T.& Subramaniam, Saravanan…[et al.]. 2010. Investigation of Antidiabetic, Antihyperlipidemic, and In Vivo Antioxidant Properties of Sphaeranthus indicus Linn. in Type 1 Diabetic Rats : An Identification of Possible Biomarkers. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-481695
Modern Language Association (MLA)
Ramachandran, S.…[et al.]. Investigation of Antidiabetic, Antihyperlipidemic, and In Vivo Antioxidant Properties of Sphaeranthus indicus Linn. in Type 1 Diabetic Rats : An Identification of Possible Biomarkers. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-481695
American Medical Association (AMA)
Ramachandran, S.& Asokkumar, K.& Uma Maheswari, M.& Ravi, T. K.& Sivashanmugam, A. T.& Subramaniam, Saravanan…[et al.]. Investigation of Antidiabetic, Antihyperlipidemic, and In Vivo Antioxidant Properties of Sphaeranthus indicus Linn. in Type 1 Diabetic Rats : An Identification of Possible Biomarkers. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-481695
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481695