Induction of Metastatic Gastric Cancer by Peroxisome Proliferator-Activated Receptorδ Activation
Joint Authors
Pollock, Claire B.
Kopelovich, Levy
Albanese, Chris
Glazer, Robert I.
Rodriguez, Olga
Li, Xin
Martin, Philip L.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptorδ (PPARδ) regulates a multiplicity of physiological processes associated with glucose and lipid metabolism, inflammation, and proliferation.
One or more of these processes likely create risk factors associated with the ability of PPARδ agonists to promote tumorigenesis in some organs.
In the present study, we describe a new gastric tumor mouse model that is dependent on the potent and highly selective PPARδ agonist GW501516 following carcinogen administration.
The progression of gastric tumorigenesis was rapid as determined by magnetic resonance imaging and resulted in highly metastatic squamous cell carcinomas of the forestomach within two months.
Tumorigenesis was associated with gene expression signatures indicative of cell adhesion, invasion, inflammation, and metabolism.
Increased PPARδ expression in tumors correlated with increased PDK1, Akt, β-catenin, and S100A9 expression.
The rapid development of metastatic gastric tumors in this model will be useful for evaluating preventive and therapeutic interventions in this disease.
American Psychological Association (APA)
Pollock, Claire B.& Rodriguez, Olga& Martin, Philip L.& Albanese, Chris& Li, Xin& Kopelovich, Levy…[et al.]. 2010. Induction of Metastatic Gastric Cancer by Peroxisome Proliferator-Activated Receptorδ Activation. PPAR Research،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-481705
Modern Language Association (MLA)
Pollock, Claire B.…[et al.]. Induction of Metastatic Gastric Cancer by Peroxisome Proliferator-Activated Receptorδ Activation. PPAR Research No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-481705
American Medical Association (AMA)
Pollock, Claire B.& Rodriguez, Olga& Martin, Philip L.& Albanese, Chris& Li, Xin& Kopelovich, Levy…[et al.]. Induction of Metastatic Gastric Cancer by Peroxisome Proliferator-Activated Receptorδ Activation. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-481705
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481705