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Tumor Regression Grades : Can They Influence Rectal Cancer Therapy Decision Tree?
Joint Authors
Nogueira, Carlos
Matos, Eduarda
Rocha, Anabela
Silva, Cristina
Santos, Marisa D.
Lopes, Carlos
Source
International Journal of Surgical Oncology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Evaluating impact of tumor regression grade in prognosis of patients with locally advanced rectal cancer (LARC).
Materials and Methods.
We identified from our colorectal cancer database 168 patients with LARC who received neoadjuvant therapy followed by complete mesorectum excision surgery between 2003 and 2011: 157 received 5-FU-based chemoradiation (CRT) and 11 short course RT.
We excluded 29 patients, the remaining 139 were reassessed for disease recurrence and survival; the slides of surgical specimens were reviewed and classified according to Mandard tumor regression grades (TRG).
We compared patients with good response (Mandard TRG1 or TRG2) versus patients with bad response (Mandard TRG3, TRG4, or TRG5).
Outcomes evaluated were 5-year overall survival (OS), disease-free survival (DFS), local, distant and mixed recurrence.
Results.
Mean age was 64.2 years, and median followup was 56 months.
No statistically significant survival difference was found when comparing patients with Mandard TRG1 versus Mandard TRG2 (p=.77).
Mandard good responders (TRG1 + 2) have significantly better OS and DFS than Mandard bad responders (TRG3 + 4 + 5) (OS p=.013; DFS p=.007).
Conclusions.
Mandard good responders had a favorable prognosis.
Tumor response (TRG) to neoadjuvant chemoradiation should be taken into account when defining the optimal adjuvant chemotherapy regimen for patients with LARC.
American Psychological Association (APA)
Santos, Marisa D.& Silva, Cristina& Rocha, Anabela& Matos, Eduarda& Nogueira, Carlos& Lopes, Carlos. 2013. Tumor Regression Grades : Can They Influence Rectal Cancer Therapy Decision Tree?. International Journal of Surgical Oncology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-481738
Modern Language Association (MLA)
Santos, Marisa D.…[et al.]. Tumor Regression Grades : Can They Influence Rectal Cancer Therapy Decision Tree?. International Journal of Surgical Oncology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-481738
American Medical Association (AMA)
Santos, Marisa D.& Silva, Cristina& Rocha, Anabela& Matos, Eduarda& Nogueira, Carlos& Lopes, Carlos. Tumor Regression Grades : Can They Influence Rectal Cancer Therapy Decision Tree?. International Journal of Surgical Oncology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-481738
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481738