Oxidative Stress in Neurodegeneration
Joint Authors
Pant, Harish C.
Shukla, Varsha
Mishra, Santosh K.
Source
Advances in Pharmacological Sciences
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
It has been demonstrated that oxidative stress has a ubiquitous role in neurodegenerative diseases.
Major source of oxidative stress due to reactive oxygen species (ROS) is related to mitochondria as an endogenous source.
Although there is ample evidence from tissues of patients with neurodegenerative disorders of morphological, biochemical, and molecular abnormalities in mitochondria, it is still not very clear whether the oxidative stress itself contributes to the onset of neurodegeneration or it is part of the neurodegenerative process as secondary manifestation.
This paper begins with an overview of how oxidative stress occurs, discussing various oxidants and antioxidants, and role of oxidative stress in diseases in general.
It highlights the role of oxidative stress in neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's diseases and amyotrophic lateral sclerosis.
The last part of the paper describes the role of oxidative stress causing deregulation of cyclin-dependent kinase 5 (Cdk5) hyperactivity associated with neurodegeneration.
American Psychological Association (APA)
Shukla, Varsha& Mishra, Santosh K.& Pant, Harish C.. 2011. Oxidative Stress in Neurodegeneration. Advances in Pharmacological Sciences،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-481785
Modern Language Association (MLA)
Shukla, Varsha…[et al.]. Oxidative Stress in Neurodegeneration. Advances in Pharmacological Sciences No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-481785
American Medical Association (AMA)
Shukla, Varsha& Mishra, Santosh K.& Pant, Harish C.. Oxidative Stress in Neurodegeneration. Advances in Pharmacological Sciences. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-481785
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481785