Antiviral and Virucidal Activities of Nα-Cocoyl-L-Arginine Ethyl Ester
Joint Authors
Yamasaki, Hisashi
Tsujimoto, Kazuko
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Various amino acid-derived compounds, for example, Nα-Cocoyl-L-arginine ethyl ester (CAE), alkyloxyhydroxylpropylarginine, arginine cocoate, and cocoyl glycine potassium salt (Amilite), were examined for their virucidal activities against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2), influenza A virus (IAV), and poliovirus type 1 (PV-1) in comparison to benzalkonium chloride (BKC) and sodium dodecylsulfate (SDS) as a cationic and anionic control detergent and also to other commercially available disinfectants.
While these amino acid-derived compounds were all effective against HSV-1 and HSV-2, CAE and Amilite were the most effective.
These two compounds were, however, not as effective against IAV, another enveloped virus, as against HSV.
Cytotoxicity of CAE was weak; at 0.012%, only 5% of the cells were killed under the conditions, in which 100% cells were killed by either SDS or BKC.
In addition to these direct virucidal effects, CAE inhibited the virus growth in the HSV-1- or PV-1-infected cells even at 0.01%.
These results suggest a potential application of CAE as a therapeutic or preventive medicine against HSV superficial infection at body surface.
American Psychological Association (APA)
Yamasaki, Hisashi& Tsujimoto, Kazuko. 2011. Antiviral and Virucidal Activities of Nα-Cocoyl-L-Arginine Ethyl Ester. Advances in Virology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-481812
Modern Language Association (MLA)
Yamasaki, Hisashi& Tsujimoto, Kazuko. Antiviral and Virucidal Activities of Nα-Cocoyl-L-Arginine Ethyl Ester. Advances in Virology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-481812
American Medical Association (AMA)
Yamasaki, Hisashi& Tsujimoto, Kazuko. Antiviral and Virucidal Activities of Nα-Cocoyl-L-Arginine Ethyl Ester. Advances in Virology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-481812
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481812