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Use of a Designed Peptide Library to Screen for Binders to a Particular DNA G-Quadruplex Sequence
Joint Authors
Kobayashi, Keita
Usui, Kenji
Matsui, Noriko
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We demonstrated a method to screen for binders to a particular G-quadruplex sequence using easily designed short peptides consisting of naturally occurring amino acids and mining of binding data using statistical methods such as hierarchical clustering analysis (HCA).
Despite the small size of the library used in this study, candidates of specific binders were identified.
In addition, a selected peptide stabilized the G-quadruplex structure of a DNA oligonucleotide derived from the promoter region of the protooncogene c-MYC.
This study illustrates how a peptide library can be designed and presents a screening guideline for construction of G-quadruplex binders.
Such G-quadruplex peptide binders could be functionally modified to enable switching, cellular penetration, and organelle-targeting for cell and tissue engineering.
American Psychological Association (APA)
Kobayashi, Keita& Matsui, Noriko& Usui, Kenji. 2011. Use of a Designed Peptide Library to Screen for Binders to a Particular DNA G-Quadruplex Sequence. Journal of Nucleic Acids،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-481813
Modern Language Association (MLA)
Kobayashi, Keita…[et al.]. Use of a Designed Peptide Library to Screen for Binders to a Particular DNA G-Quadruplex Sequence. Journal of Nucleic Acids No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-481813
American Medical Association (AMA)
Kobayashi, Keita& Matsui, Noriko& Usui, Kenji. Use of a Designed Peptide Library to Screen for Binders to a Particular DNA G-Quadruplex Sequence. Journal of Nucleic Acids. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-481813
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481813