Downregulation of Transketolase Activity Is Related to Inhibition of Hippocampal Progenitor Cell Proliferation Induced by Thiamine Deficiency
Joint Authors
Ni, Xiushi
Ning, Min
Wu, Yiying
Zhao, Yanling
Cai, Jinghui
Zhong, Chunjiu
Hu, Haolu
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In animal experiments, hippocampal neurogenesis and the activity of thiamine-dependent transketolase decrease markedly under conditions of thiamine deficiency.
To further investigate the effect of thiamine deficiency on the proliferation of hippocampal progenitor cells (HPCs) and the potential mechanisms involved in this effect, we cultured HPCs in vitro in the absence of thiamine and found that proliferation and transketolase activity were both significantly repressed.
Furthermore, specific inhibition of transketolase activity by oxythiamine strongly inhibited HPC proliferation in a dose-dependent manner.
However, thiamine deficiency itself inhibited the proliferation to a greater degree than did oxythiamine.
Taken together, our results suggest that modulation of transketolase activity might be one of the mechanisms by which thiamine regulates the proliferation of hippocampal progenitor cells.
American Psychological Association (APA)
Zhao, Yanling& Wu, Yiying& Hu, Haolu& Cai, Jinghui& Ning, Min& Ni, Xiushi…[et al.]. 2014. Downregulation of Transketolase Activity Is Related to Inhibition of Hippocampal Progenitor Cell Proliferation Induced by Thiamine Deficiency. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-481818
Modern Language Association (MLA)
Zhao, Yanling…[et al.]. Downregulation of Transketolase Activity Is Related to Inhibition of Hippocampal Progenitor Cell Proliferation Induced by Thiamine Deficiency. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-481818
American Medical Association (AMA)
Zhao, Yanling& Wu, Yiying& Hu, Haolu& Cai, Jinghui& Ning, Min& Ni, Xiushi…[et al.]. Downregulation of Transketolase Activity Is Related to Inhibition of Hippocampal Progenitor Cell Proliferation Induced by Thiamine Deficiency. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-481818
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481818