The Parameters of Transcutaneous Electrical Nerve Stimulation Are Critical to Its Regenerative Effects When Applied Just after a Sciatic Crush Lesion in Mice
Joint Authors
Martinez, Ana Maria Blanco
Martins Lima, Êmyle
Baptista, Abrahão Fontes
Teixeira Goes, Bruno
Zugaib Cavalcanti, João
Barbosa Paixão, Alaí
Vannier-Santos, Marcos André
Cavalcante Miranda de Assis, Diana
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We investigated the effect of two frequencies of transcutaneous electrical nerve stimulation (TENS) applied immediately after lesion on peripheral nerve regeneration after a mouse sciatic crush injury.
The animals were anesthetized and subjected to crushing of the right sciatic nerve and then separated into three groups: nontreated, Low-TENS (4 Hz), and High-TENS (100 Hz).
The animals of Low- and High-TENS groups were stimulated for 2 h immediately after the surgical procedure, while the nontreated group was only positioned for the same period.
After five weeks the animals were euthanized, and the nerves dissected bilaterally for histological and histomorphometric analysis.
Histological assessment by light and electron microscopy showed that High-TENS and nontreated nerves had a similar profile, with extensive signs of degeneration.
Conversely, Low-TENS led to increased regeneration, displaying histological aspects similar to control nerves.
High-TENS also led to decreased density of fibers in the range of 6–12 μm diameter and decreased fiber diameter and myelin area in the range of 0–2 μm diameter.
These findings suggest that High-TENS applied just after a peripheral nerve crush may be deleterious for regeneration, whereas Low-TENS may increase nerve regeneration capacity.
American Psychological Association (APA)
Cavalcante Miranda de Assis, Diana& Martins Lima, Êmyle& Teixeira Goes, Bruno& Zugaib Cavalcanti, João& Barbosa Paixão, Alaí& Vannier-Santos, Marcos André…[et al.]. 2014. The Parameters of Transcutaneous Electrical Nerve Stimulation Are Critical to Its Regenerative Effects When Applied Just after a Sciatic Crush Lesion in Mice. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-481823
Modern Language Association (MLA)
Cavalcante Miranda de Assis, Diana…[et al.]. The Parameters of Transcutaneous Electrical Nerve Stimulation Are Critical to Its Regenerative Effects When Applied Just after a Sciatic Crush Lesion in Mice. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-481823
American Medical Association (AMA)
Cavalcante Miranda de Assis, Diana& Martins Lima, Êmyle& Teixeira Goes, Bruno& Zugaib Cavalcanti, João& Barbosa Paixão, Alaí& Vannier-Santos, Marcos André…[et al.]. The Parameters of Transcutaneous Electrical Nerve Stimulation Are Critical to Its Regenerative Effects When Applied Just after a Sciatic Crush Lesion in Mice. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-481823
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481823