Modeling of Tau-Mediated Synaptic and Neuronal Degeneration in Alzheimer's Disease
Joint Authors
Kügler, Sebastian
Van Leuven, Fred
Jaworski, Tomasz
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Patients suffering from Alzheimer's disease (AD) are typified and diagnosed postmortem by the combined accumulations of extracellular amyloid plaques and of intracellular tauopathy, consisting of neuropil treads and neurofibrillary tangles in the somata.
Both hallmarks are inseparable and remain diagnostic as described by Alois Alzheimer more than a century ago.
Nevertheless, these pathological features are largely abandoned as being the actual pathogenic or neurotoxic factors.
The previous, almost exclusive experimental attention on amyloid has shifted over the last 10 years in two directions.
Firstly, from the “concrete” deposits of amyloid plaques to less well-defined soluble or pseudosoluble oligomers of the amyloid peptides, ranging from dimers to dodecamers and even larger aggregates.
A second shift in research focus is from amyloid to tauopathy, and to their mutual relation.
The role of Tau in the pathogenesis and disease progression is appreciated as leading to synaptic and neuronal loss, causing cognitive deficits and dementia.
Both trends are incorporated in a modified amyloid cascade hypothesis, briefly discussed in this paper that is mainly concerned with the second aspect, that is, protein Tau and its associated fundamental questions.
American Psychological Association (APA)
Jaworski, Tomasz& Kügler, Sebastian& Van Leuven, Fred. 2010. Modeling of Tau-Mediated Synaptic and Neuronal Degeneration in Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-481842
Modern Language Association (MLA)
Jaworski, Tomasz…[et al.]. Modeling of Tau-Mediated Synaptic and Neuronal Degeneration in Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-481842
American Medical Association (AMA)
Jaworski, Tomasz& Kügler, Sebastian& Van Leuven, Fred. Modeling of Tau-Mediated Synaptic and Neuronal Degeneration in Alzheimer's Disease. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-481842
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481842