Immunosuppressive Exosomes : A New Approach for Treating Arthritis
Joint Authors
Source
International Journal of Rheumatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Rheumatoid arthritis (RA) is a chronic autoimmune disease and one of the leading causes of disability in the USA.
Although certain biological therapies, including protein and antibodies targeting inflammatory factors such as the tumor necrosis factor, are effective in reducing symptoms of RA, these treatments do not reverse disease.
Also, although novel gene therapy approaches have shown promise in preclinical and clinical studies to treat RA, it is still unclear whether gene therapy can be readily and safely applied to treat the large number of RA patients.
Recently, nanosized, endocytic-derived membrane vesicles “exosomes” were demonstrated to function in cell-to-cell communication and to possess potent immunoregulatory properties.
In particular, immunosuppressive DC-derived exosomes and blood plasma- or serum-derived exosomes have shown potent therapeutic effects in animal models of inflammatory and autoimmune disease including RA.
This paper discusses the current knowledge on the production, efficacy, mechanism of action, and potential therapeutic use of immunosuppressive exosomes for arthritis therapy.
American Psychological Association (APA)
Yang, Chenjie& Robbins, Paul D.. 2012. Immunosuppressive Exosomes : A New Approach for Treating Arthritis. International Journal of Rheumatology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-481875
Modern Language Association (MLA)
Yang, Chenjie& Robbins, Paul D.. Immunosuppressive Exosomes : A New Approach for Treating Arthritis. International Journal of Rheumatology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-481875
American Medical Association (AMA)
Yang, Chenjie& Robbins, Paul D.. Immunosuppressive Exosomes : A New Approach for Treating Arthritis. International Journal of Rheumatology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-481875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481875