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K-ras Mutational Status in Cytohistological Tissue as a Molecular Marker for the Diagnosis of Pancreatic Cancer : A Systematic Review and Meta-Analysis
Joint Authors
Lu, Jie
Li, Jingjing
Wang, Junshan
Wang, Fan
Zhang, Huawei
Yang, Jing
Shen, Miao
Zheng, Yuanyuan
Cheng, Ping
Wang, Chengfen
Xia, Yujing
Zhou, Ying-Qun
Chen, Kan
Zhu, Rong
Zhang, Yan
Guo, Chuan-Yong
Weiqi, Dai
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
More clinically meaningful diagnostic tests are needed in pancreatic cancer (PC).
K-ras mutations are the most frequently acquired genetic alteration.
Methods.
Original research articles involving the diagnostic accuracy of K-ras mutation detection in PC were selected.
Data were presented as forest plots and summary receiver operating characteristic (SROC) curve analysis was used to summarize the overall test performance.
Results.
We assessed 19 studies from 16 published articles.
The reports were divided into three groups according to the process used to obtain the test material.
The summary estimates for detecting K-ras status using an invasive method (fine needle aspiration (FNA), endoscopic retrograde cholangiopancreatography (ERCP), or surgery) were better than cytology: the pooled sensitivity was 77% (95% confidence interval (CI): 74–80%) versus 54% (95% CI: 47–61%); specificity was 88% (95% CI: 85–91%) versus 91% (95% CI: 83–96%); and diagnostic odds ratio (DOR) was 20.26 (11.40–36.03) versus 7.52 (95% CI: 2.80–20.18), respectively.
When two procedures were combined, the diagnostic accuracy was markedly improved.
Conclusions.
The analysis of K-ras mutations in pancreatic tissue has a promising diagnostic significance in PC.
Further valuable studies are needed.
American Psychological Association (APA)
Yang, Jing& Li, Jingjing& Zhu, Rong& Zhang, Huawei& Zheng, Yuanyuan& Weiqi, Dai…[et al.]. 2014. K-ras Mutational Status in Cytohistological Tissue as a Molecular Marker for the Diagnosis of Pancreatic Cancer : A Systematic Review and Meta-Analysis. Disease Markers،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-481900
Modern Language Association (MLA)
Yang, Jing…[et al.]. K-ras Mutational Status in Cytohistological Tissue as a Molecular Marker for the Diagnosis of Pancreatic Cancer : A Systematic Review and Meta-Analysis. Disease Markers No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-481900
American Medical Association (AMA)
Yang, Jing& Li, Jingjing& Zhu, Rong& Zhang, Huawei& Zheng, Yuanyuan& Weiqi, Dai…[et al.]. K-ras Mutational Status in Cytohistological Tissue as a Molecular Marker for the Diagnosis of Pancreatic Cancer : A Systematic Review and Meta-Analysis. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-481900
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481900