Active Roles of Tumor Stroma in Breast Cancer Metastasis
Joint Authors
Sahab, Ziad J.
Khamis, Zahraa I.
Sang, Qing-Xiang Amy
Source
International Journal of Breast Cancer
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Metastasis is the major cause of death for breast cancer patients.
Tumors are heterogenous cellular entities composed of cancer cells and cells of the microenvironment in which they reside.
A reciprocal dynamic interaction occurs between the tumor cells and their surrounding stroma under physiological and pathological conditions.
This tumor-host communication interface mediates the escape of tumor cells at the primary site, survival of circulating cancer cells in the vasculature, and growth of metastatic cancer at secondary site.
Each step of the metastatic process is accompanied by recruitment of stromal cells from the microenvironment and production of unique array of growth factors and chemokines.
Stromal microenvironment may play active roles in breast cancer metastasis.
Elucidating the types of cells recruited and signal pathways involved in the crosstalk between tumor cells and stromal cells will help identify novel strategies for cotargeting cancer cells and tumor stromal cells to suppress metastasis and improve patient outcome.
American Psychological Association (APA)
Khamis, Zahraa I.& Sahab, Ziad J.& Sang, Qing-Xiang Amy. 2012. Active Roles of Tumor Stroma in Breast Cancer Metastasis. International Journal of Breast Cancer،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-481922
Modern Language Association (MLA)
Khamis, Zahraa I.…[et al.]. Active Roles of Tumor Stroma in Breast Cancer Metastasis. International Journal of Breast Cancer No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-481922
American Medical Association (AMA)
Khamis, Zahraa I.& Sahab, Ziad J.& Sang, Qing-Xiang Amy. Active Roles of Tumor Stroma in Breast Cancer Metastasis. International Journal of Breast Cancer. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-481922
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481922