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Resveratrol Prevents Dendritic Cell Maturation in Response to Advanced Glycation End Products
Joint Authors
Ozturk, Elif Inci
Buttari, Brigitta
Facchiano, Francesco
Segoni, Luca
Riganò, Rachele
Profumo, Elisabetta
Saso, Luciano
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Advanced glycation end products (AGEs), generated through nonenzymatic glycosylation of proteins, lipids, and nucleic acids, accumulate in the body by age thus being considered as biomarkers of senescence.
Senescence is characterized by a breakdown of immunological self-tolerance, resulting in increased reactivity to self-antigens.
Previous findings suggest that AGE and its receptor RAGE may be involved in the pathogenesis of autoimmune reactions through dendritic cell (DC) activation.
The aim of this study was to investigate whether resveratrol, a polyphenolic antioxidant compound with tolerogenic effects on DCs, was able to counteract the mechanisms triggered by AGE/RAGE interaction on DCs.
By immunochemical and cytofluorimetric assays, we demonstrated that in vitro pretreatment of human monocyte-derived DCs with resveratrol prevents DC activation in response to glucose-treated albumin (AGE-albumin).
We found that resveratrol exerts an inhibitory effect on DC surface maturation marker and RAGE up-regulation in response to AGE-albumin.
It also inhibited proinflammatory cytokine expression, allostimulatory ability upregulation, mitogen-activated protein (MAP) kinases, and NF-κB activation in AGE-albumin-stimulated DCs.
We suggest that resveratrol, by dismantling AGE/RAGE signaling on DCs may prevent or reduce increased reactivity to self-molecules in aging.
American Psychological Association (APA)
Buttari, Brigitta& Profumo, Elisabetta& Facchiano, Francesco& Ozturk, Elif Inci& Segoni, Luca& Saso, Luciano…[et al.]. 2013. Resveratrol Prevents Dendritic Cell Maturation in Response to Advanced Glycation End Products. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-481923
Modern Language Association (MLA)
Buttari, Brigitta…[et al.]. Resveratrol Prevents Dendritic Cell Maturation in Response to Advanced Glycation End Products. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-481923
American Medical Association (AMA)
Buttari, Brigitta& Profumo, Elisabetta& Facchiano, Francesco& Ozturk, Elif Inci& Segoni, Luca& Saso, Luciano…[et al.]. Resveratrol Prevents Dendritic Cell Maturation in Response to Advanced Glycation End Products. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-481923
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481923