PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma
Joint Authors
Kondo, Yasuteru
Shimosegawa, Tooru
Kimura, Osamu
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Viral hepatitis with hepatitis C virus or hepatitis B virus and chronic liver disease such as alcoholic or nonalcoholic steatohepatitis are critical factors in the development of hepatocellular carcinoma (HCC).
Furthermore, diabetes is known as an independent risk factor for HCC.
Peroxisome proliferator-activated receptor (PPAR) is known to have an important role in fatty liver, and the mechanism of carcinogenesis has been clarified.
PPAR controls ligand-dependent transcription, and three subtypes (α, δ, and γ) in humans are known.
PPARs could contribute to the mechanisms of cell cycling, anti-inflammatory responses, and apoptosis.
Therefore, to clarify the pathogenesis of HCC, we should examine PPAR signaling.
In this paper, we have summarized the relevance of PPARs to the pathogenesis of HCC and cancer stem cells and possible therapeutic options through modifying PPAR signaling.
American Psychological Association (APA)
Kimura, Osamu& Kondo, Yasuteru& Shimosegawa, Tooru. 2012. PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma. PPAR Research،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-481932
Modern Language Association (MLA)
Kimura, Osamu…[et al.]. PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma. PPAR Research No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-481932
American Medical Association (AMA)
Kimura, Osamu& Kondo, Yasuteru& Shimosegawa, Tooru. PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-481932
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481932