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Extraction of Nucleolus Candidate Zone in White Blood Cells of Peripheral Blood Smear Images Using Curvelet Transform
Joint Authors
Talebi, Ardeshir
Rabbani, Hossein
Soltanzadeh, Ramin
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The main part of each white blood cell (WBC) is its nucleus which contains chromosomes.
Although white blood cells (WBCs) with giant nuclei are the main symptom of leukemia, they are not sufficient to prove this disease and other symptoms must be investigated.
For example another important symptom of leukemia is the existence of nucleolus in nucleus.
The nucleus contains chromatin and a structure called the nucleolus.
Chromatin is DNA in its active form while nucleolus is composed of protein and RNA, which are usually inactive.
In this paper, to diagnose this symptom and in order to discriminate between nucleoli and chromatins, we employ curvelet transform, which is a multiresolution transform for detecting 2D singularities in images.
For this reason, at first nuclei are extracted by means of K-means method, then curvelet transform is applied on extracted nuclei and the coefficients are modified, and finally reconstructed image is used to extract the candidate locations of chromatins and nucleoli.
This method is applied on 100 microscopic images and succeeds with specificity of 80.2% and sensitivity of 84.3% to detect the nucleolus candidate zone.
After nucleolus candidate zone detection, new features that can be used to classify atypical and blast cells such as gradient of saturation channel are extracted.
American Psychological Association (APA)
Soltanzadeh, Ramin& Rabbani, Hossein& Talebi, Ardeshir. 2012. Extraction of Nucleolus Candidate Zone in White Blood Cells of Peripheral Blood Smear Images Using Curvelet Transform. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-481933
Modern Language Association (MLA)
Soltanzadeh, Ramin…[et al.]. Extraction of Nucleolus Candidate Zone in White Blood Cells of Peripheral Blood Smear Images Using Curvelet Transform. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-481933
American Medical Association (AMA)
Soltanzadeh, Ramin& Rabbani, Hossein& Talebi, Ardeshir. Extraction of Nucleolus Candidate Zone in White Blood Cells of Peripheral Blood Smear Images Using Curvelet Transform. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-481933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481933