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Estimated Visceral Adipose Tissue, but Not Body Mass Index, Is Associated with Reductions in Glomerular Filtration Rate Based on Cystatin C in the Early Stages of Chronic Kidney Disease
Joint Authors
França, Ana Karina Teixeira da Cunha
Salgado, João Victor
Hortegal, Elane Viana
Salgado Filho, Natalino
Santos, Alcione Miranda dos
Silva, Antônio Augusto Moura da
Source
International Journal of Nephrology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Information on the association between obesity and initial phases of chronic kidney disease (CKD) is still limited, principally those regarding the influence of visceral adipose tissue.
We investigated whether the visceral adipose tissue is more associated with reductions in glomerular filtration rate (GFR) than total and abdominal obesity in hypertensive individuals with stage 1-2 CKD.
A cross-sectional study was implemented which involved 241 hypertensive patients undergoing treatment at a primary health care facility.
GFR was estimated using equations based on creatinine and cystatin C levels.
Explanatory variables included body mass index (BMI), waist circumference (WC), and estimated visceral adipose tissue (eVAT).
The mean age was 59.6±9.2 years old and 75.9% were female.
According to BMI, 28.2% of subjects were obese.
Prevalence of increased WC and eVAT was 63.9% and 58.5%, respectively.
Results from the assessment of GFR by BMI, WC, and eVAT categories showed that only women with increased eVAT (≥150 cm2) had a lower mean GFR by Larsson (P=0.016), Levey 2 (P=0.005), and Levey 3 (P=0.008) equations.
The same result was not observed when the MDRD equation was employed.
No association was found between BMI, WC, eVAT, and GFR using only serum creatinine.
In the early stages of CKD, increased eVAT in hypertensive women was associated with decreased GFR based on cystatin C.
American Psychological Association (APA)
França, Ana Karina Teixeira da Cunha& Santos, Alcione Miranda dos& Salgado, João Victor& Hortegal, Elane Viana& Silva, Antônio Augusto Moura da& Salgado Filho, Natalino. 2014. Estimated Visceral Adipose Tissue, but Not Body Mass Index, Is Associated with Reductions in Glomerular Filtration Rate Based on Cystatin C in the Early Stages of Chronic Kidney Disease. International Journal of Nephrology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-481945
Modern Language Association (MLA)
França, Ana Karina Teixeira da Cunha…[et al.]. Estimated Visceral Adipose Tissue, but Not Body Mass Index, Is Associated with Reductions in Glomerular Filtration Rate Based on Cystatin C in the Early Stages of Chronic Kidney Disease. International Journal of Nephrology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-481945
American Medical Association (AMA)
França, Ana Karina Teixeira da Cunha& Santos, Alcione Miranda dos& Salgado, João Victor& Hortegal, Elane Viana& Silva, Antônio Augusto Moura da& Salgado Filho, Natalino. Estimated Visceral Adipose Tissue, but Not Body Mass Index, Is Associated with Reductions in Glomerular Filtration Rate Based on Cystatin C in the Early Stages of Chronic Kidney Disease. International Journal of Nephrology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-481945
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481945