Modeling to Optimize Terminal Stem Cell Differentiation
Author
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-11
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Diseases
Abstract EN
Embryonic stem cell (ESC), iPCs, and adult stem cells (ASCs) all are among the most promising potential treatments for heart failure, spinal cord injury, neurodegenerative diseases, and diabetes.
However, considerable uncertainty in the production of ESC-derived terminally differentiated cell types has limited the efficiency of their development.
To address this uncertainty, we and other investigators have begun to employ a comprehensive statistical model of ESC differentiation for determining the role of intracellular pathways (e.g., STAT3) in ESC differentiation and determination of germ layer fate.
The approach discussed here applies the Baysian statistical model to cell/developmental biology combining traditional flow cytometry methodology and specific morphological observations with advanced statistical and probabilistic modeling and experimental design.
The final result of this study is a unique tool and model that enhances the understanding of how and when specific cell fates are determined during differentiation.
This model provides a guideline for increasing the production efficiency of therapeutically viable ESCs/iPSCs/ASC derived neurons or any other cell type and will eventually lead to advances in stem cell therapy.
American Psychological Association (APA)
Gallicano, G. Ian. 2013. Modeling to Optimize Terminal Stem Cell Differentiation. Scientifica،Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-481951
Modern Language Association (MLA)
Gallicano, G. Ian. Modeling to Optimize Terminal Stem Cell Differentiation. Scientifica No. 2013 (2013), pp.1-20.
https://search.emarefa.net/detail/BIM-481951
American Medical Association (AMA)
Gallicano, G. Ian. Modeling to Optimize Terminal Stem Cell Differentiation. Scientifica. 2013. Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-481951
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481951