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Characterization of Ex Vivo Expanded Tumor Infiltrating Lymphocytes from Patients with Malignant Melanoma for Clinical Application
Joint Authors
Andersen, Mads Hald
Junker, Niels
thor Straten, Per
Svane, Inge Marie
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Clinical trials of adoptive transfer of autologous tumor infiltrating lymphocytes (TILs) to patients with advanced malignant melanoma have shown remarkable results with objective clinical responses in 50% of the treated patients.
In order to initiate a clinical trial in melanoma, we have established a method for expanding TILs to clinical relevant quantities in two steps with in 8 weeks.
Further characterization of expanded TILs revealed an oligoclonal composition of T-cells with an effector memory like phenotype.
When autologous tumor was available, TILs showed specific activity in all patients tested.
TIL cultures contained specificity towards tumor cells as well as peptides derived from tumor-associated antigens (TAAs) during expansion procedures.
American Psychological Association (APA)
Junker, Niels& thor Straten, Per& Andersen, Mads Hald& Svane, Inge Marie. 2011. Characterization of Ex Vivo Expanded Tumor Infiltrating Lymphocytes from Patients with Malignant Melanoma for Clinical Application. Journal of Skin Cancer،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-481973
Modern Language Association (MLA)
Junker, Niels…[et al.]. Characterization of Ex Vivo Expanded Tumor Infiltrating Lymphocytes from Patients with Malignant Melanoma for Clinical Application. Journal of Skin Cancer No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-481973
American Medical Association (AMA)
Junker, Niels& thor Straten, Per& Andersen, Mads Hald& Svane, Inge Marie. Characterization of Ex Vivo Expanded Tumor Infiltrating Lymphocytes from Patients with Malignant Melanoma for Clinical Application. Journal of Skin Cancer. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-481973
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481973