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Metal Preferences of Zinc-Binding Motif on Metalloproteases
Joint Authors
Hata, Toshiyuki
Fukasawa, Kayoko M.
Hirose, Junzo
Ono, Yukio
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Almost all naturally occurring metalloproteases are monozinc enzymes.
The zinc in any number of zinc metalloproteases has been substituted by some other divalent cation.
Almost all Co(II)- or Mn(II)-substituted enzymes maintain the catalytic activity of their zinc counterparts.
However, in the case of Cu(II) substitution of zinc proteases, a great number of enzymes are not active, for example, thermolysin, carboxypeptidase A, endopeptidase from Lactococcus lactis, or aminopeptidase B, while some do have catalytic activity, for example, astacin (37%) and DPP III (100%).
Based on structural studies of various metal-substituted enzymes, for example, thermolysin, astacin, aminopeptidase B, dipeptidyl peptidase (DPP) III, and del-DPP III, the metal coordination geometries of both active and inactive Cu(II)-substituted enzymes are shown to be the same as those of the wild-type Zn(II) enzymes.
Therefore, the enzyme activity of a copper-ion-substituted zinc metalloprotease may depend on the flexibility of catalytic domain.
American Psychological Association (APA)
Fukasawa, Kayoko M.& Hata, Toshiyuki& Ono, Yukio& Hirose, Junzo. 2011. Metal Preferences of Zinc-Binding Motif on Metalloproteases. Journal of Amino Acids،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-481981
Modern Language Association (MLA)
Fukasawa, Kayoko M.…[et al.]. Metal Preferences of Zinc-Binding Motif on Metalloproteases. Journal of Amino Acids No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-481981
American Medical Association (AMA)
Fukasawa, Kayoko M.& Hata, Toshiyuki& Ono, Yukio& Hirose, Junzo. Metal Preferences of Zinc-Binding Motif on Metalloproteases. Journal of Amino Acids. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-481981
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481981