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Heavy Silicone Oil and Intraocular Inflammation
Joint Authors
Duse, Sarah
Romano, Mario R.
Semeraro, Francesco
Arcidiacono, Barbara
Morescalchi, Francesco
Parolini, Barbara
Gambicorti, Elena
Costagliola, Ciro
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-07
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
In the past two decades, many advances have been made in vitrectomy instrumentation, surgical techniques, and the use of different tamponade agents.
These agents serve close retinal breaks, confine eventual retinal redetachment, and prevent proliferative vitreoretinopathy (PVR).
Long-acting gases and silicone oil are effective internal tamponade agents; however, because their specific gravity is lower than that of the vitreous fluid, they may provide adequate support for the superior retina but lack efficacy for the inferior retina, especially when the fill is subtotal.
Thus, a specific role may exist for an internal tamponade agent with a higher specific gravity, such as heavy silicone oils (HSOs), Densiron 68, Oxane HD, HWS 45-300, HWS 46-3000, and HeavySil.
Some clinical evidence seems to presume that heavy tamponades are more prone to intraocular inflammation than standard silicone if they remain in the eye for several months.
In this review, we discuss the fundamental clinical and biochemical/molecular mechanisms involved in the inflammatory response after the use of heavy tamponade: toxicity due to impurities or instability of the agent, direct toxicity and immunogenicity, oil emulsification, and mechanical injury due to gravity.
The physical and chemical properties of various HSOs and their efficacy and safety profiles are also described.
American Psychological Association (APA)
Morescalchi, Francesco& Costagliola, Ciro& Duse, Sarah& Gambicorti, Elena& Parolini, Barbara& Arcidiacono, Barbara…[et al.]. 2014. Heavy Silicone Oil and Intraocular Inflammation. BioMed Research International،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-481982
Modern Language Association (MLA)
Morescalchi, Francesco…[et al.]. Heavy Silicone Oil and Intraocular Inflammation. BioMed Research International No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-481982
American Medical Association (AMA)
Morescalchi, Francesco& Costagliola, Ciro& Duse, Sarah& Gambicorti, Elena& Parolini, Barbara& Arcidiacono, Barbara…[et al.]. Heavy Silicone Oil and Intraocular Inflammation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-481982
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481982