Relationship between the Presence of the nalC Mutation and Multidrug Resistance in Pseudomonas aeruginosa
Joint Authors
Ghafourian, Sobhan
Mohebi, Reza
Maleki, Abbas
Valizadeh, Azar
Khosravi, Afra
Maleki, Mohammad Hossien
Zolfaghary, Mohammad Reza
Sadeghifard, Nourkhoda
Source
International Journal of Microbiology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-07
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Abstract EN
Objectives.
The current study was conducted to determine the relationship between the presences of significant multidrug resistance in Pseudomonas aeruginosa (P.
aeruginosa) having intact mexR genes (nalC) to different antibiotics.
Methods.
In order to identify nalC, fifty strains of P.
aeruginosa were obtained.
All isolates were found in urinary tract infections.
They were evaluated against different antibiotics.
The nalC mutant was identified by PCR.
Results.
The 50 clinical isolates of P.
aeruginosa originated from two hospitals in Iran, in which 32 isolates were found in Milad hospital, and 18 isolates were collected in the Ilam Hospital.
The results in Milad hospital of nalC revealed that all P.
aeruginosa resistant to oxacillin showed the presence of nalC.
In Ilam hospital only three (16.6%) isolates were resistant to oxacilin and aztreonam, and among these three isolates only one isolate revealed resistance to ceftazidime and amikacin.
The resistant isolates showed the presence of both OXA-10 and nalC.
Conclusion.
Our results showed that the presence of nalC was observed among P.
aeruginosa resistance to oxacilin.
Thus, the finding suggested relationship between oxacilin resistance and presence of nalC and consequently overproduction of the MexABOprM efflux system.
American Psychological Association (APA)
Sadeghifard, Nourkhoda& Valizadeh, Azar& Zolfaghary, Mohammad Reza& Maleki, Mohammad Hossien& Maleki, Abbas& Mohebi, Reza…[et al.]. 2012. Relationship between the Presence of the nalC Mutation and Multidrug Resistance in Pseudomonas aeruginosa. International Journal of Microbiology،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-482019
Modern Language Association (MLA)
Sadeghifard, Nourkhoda…[et al.]. Relationship between the Presence of the nalC Mutation and Multidrug Resistance in Pseudomonas aeruginosa. International Journal of Microbiology No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-482019
American Medical Association (AMA)
Sadeghifard, Nourkhoda& Valizadeh, Azar& Zolfaghary, Mohammad Reza& Maleki, Mohammad Hossien& Maleki, Abbas& Mohebi, Reza…[et al.]. Relationship between the Presence of the nalC Mutation and Multidrug Resistance in Pseudomonas aeruginosa. International Journal of Microbiology. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-482019
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482019