Thymidine Kinase 1 Upregulation Is an Early Event in Breast Tumor Formation
Joint Authors
Robison, Richard A.
O'Neill, Kim L.
Alegre, Melissa M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Prognostic markers play an important role in our understanding of tumors and how to treat them.
Thymidine kinase 1 (TK1), a proliferation marker involved in DNA repair, has been shown to have independent prognostic potential.
This prognostic potential includes the novel concept that upregulation of serum TK1 levels is an early event in cancer development.
This same effect may also be seen in tumor tissue.
In order to demonstrate that TK1 upregulation is an early event in tumor tissue formation, tissue arrays were obtained and stained for TK1 by immunohistochemistry.
Using a progressive breast tissue array, precancerous tissue including breast adenosis, simple hyperplasia, and atypical hyperplasia stained positive for TK1 expression.
Different stages of breast carcinoma tissue also stained positive for TK1 including nonspecific infiltrating duct, infiltrating lobular, and infiltrating duct with lymph node metastasis carcinomas.
This indicates that TK1 upregulation is an early event in breast carcinoma development, and may be useful in identifying precancerous tissue.
Further work is needed to better understand the differences seen between TK1 positive and negative tissues.
American Psychological Association (APA)
Alegre, Melissa M.& Robison, Richard A.& O'Neill, Kim L.. 2012. Thymidine Kinase 1 Upregulation Is an Early Event in Breast Tumor Formation. Journal of Oncology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-482051
Modern Language Association (MLA)
Alegre, Melissa M.…[et al.]. Thymidine Kinase 1 Upregulation Is an Early Event in Breast Tumor Formation. Journal of Oncology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-482051
American Medical Association (AMA)
Alegre, Melissa M.& Robison, Richard A.& O'Neill, Kim L.. Thymidine Kinase 1 Upregulation Is an Early Event in Breast Tumor Formation. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-482051
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482051