Lack of Association between the GPR3 Gene and the Risk for Alzheimer's Disease
Joint Authors
Dominici, Roberto
Scarpini, Elio
Ronchi, Marcello
Galimberti, Daniela
Finazzi, Dario
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-07
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Alzheimer's disease is the most frequent form of dementia and its incidence is rapidly increasing.
Genetic factors are important determinants of the individual susceptibility to the disease and many efforts have been made to identify loci and markers involved.
Recent finding describes the GPR3 gene as a modulator of β-amyloid production, suggesting that perturbation of its activity and function may contribute to the pathogenesis of AD.
Furthermore, the gene is located at chromosome 1, in a region proposed as a susceptibility locus for the disease.
We searched for nucleotide variations in the coding sequence and in the region 5 prime of it by dHPLC and analysed their distribution in a group of 104 AD patients and 109 age-matched controls.
We identified 5 types of variation, two in the putative promoter region (g.27718954A>G and g.27719102A>T) and the others in exon 2 (c.51C>A, c.80C>G, and c.771C>T).
All of them were equally represented in the two cohorts of the study, thus suggesting the absence of an association between GPR3 gene and AD in our population.
American Psychological Association (APA)
Dominici, Roberto& Ronchi, Marcello& Galimberti, Daniela& Scarpini, Elio& Finazzi, Dario. 2011. Lack of Association between the GPR3 Gene and the Risk for Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-3.
https://search.emarefa.net/detail/BIM-482086
Modern Language Association (MLA)
Dominici, Roberto…[et al.]. Lack of Association between the GPR3 Gene and the Risk for Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-3.
https://search.emarefa.net/detail/BIM-482086
American Medical Association (AMA)
Dominici, Roberto& Ronchi, Marcello& Galimberti, Daniela& Scarpini, Elio& Finazzi, Dario. Lack of Association between the GPR3 Gene and the Risk for Alzheimer's Disease. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-3.
https://search.emarefa.net/detail/BIM-482086
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482086