Evidence for Maternal-Fetal Genotype Incompatibility as a Risk Factor for Schizophrenia
Author
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Prenatal/obstetric complications are implicated in schizophrenia susceptibility.
Some complications may arise from maternal-fetal genotype incompatibility, a term used to describe maternal-fetal genotype combinations that produce an adverse prenatal environment.
A review of maternal-fetal genotype incompatibility studies suggests that schizophrenia susceptibility is increased by maternal-fetal genotype combinations at the RHD and HLA-B loci.
Maternal-fetal genotype combinations at these loci are hypothesized to have an effect on the maternal immune system during pregnancy which can affect fetal neurodevelopment and increase schizophrenia susceptibility.
This article reviews maternal-fetal genotype incompatibility studies and schizophrenia and discusses the hypothesized biological role of these ‘‘incompatibility genes’’.
It concludes that research is needed to further elucidate the role of RHD and HLA-B maternal-fetal genotype incompatibility in schizophrenia and to identify other genes that produce an adverse prenatal environment through a maternal-fetal genotype incompatibility mechanism.
Efforts to develop more sophisticated study designs and data analysis techniques for modeling maternal-fetal genotype incompatibility effects are warranted.
American Psychological Association (APA)
Palmer, Christina G. S.. 2010. Evidence for Maternal-Fetal Genotype Incompatibility as a Risk Factor for Schizophrenia. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-482103
Modern Language Association (MLA)
Palmer, Christina G. S.. Evidence for Maternal-Fetal Genotype Incompatibility as a Risk Factor for Schizophrenia. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-482103
American Medical Association (AMA)
Palmer, Christina G. S.. Evidence for Maternal-Fetal Genotype Incompatibility as a Risk Factor for Schizophrenia. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-482103
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482103