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Grape-Seed Polyphenolic Extract Improves the Eye Phenotype in a Drosophila Model of Tauopathy
Joint Authors
Vittorino, Roselle
Conley, Lindsay M.
Pasinetti, Giulio Maria
Wang, Jun
Friedman, Lauren
Pfleger, Cathie M.
Fivecoat, Hayley C.
Ho, Lap
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Drosophila models of tauopathies have been developed by transgenically overexpressing the disease-associated forms of tau.
In this paper we report for the first time that a recently developed Grape-Seed Polyphenolic Extract (GSPE) improves the eye phenotype of a Drosophila eye model of R406W tau.
GSPE-mediated improvements in this distinct in vivo neurodegeneration model for protein misfolding/aggregation suggest that GSPE may have therapeutic value in disorders involving aberrant protein aggregation.
American Psychological Association (APA)
Pfleger, Cathie M.& Wang, Jun& Friedman, Lauren& Vittorino, Roselle& Conley, Lindsay M.& Ho, Lap…[et al.]. 2010. Grape-Seed Polyphenolic Extract Improves the Eye Phenotype in a Drosophila Model of Tauopathy. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-482104
Modern Language Association (MLA)
Pfleger, Cathie M.…[et al.]. Grape-Seed Polyphenolic Extract Improves the Eye Phenotype in a Drosophila Model of Tauopathy. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-482104
American Medical Association (AMA)
Pfleger, Cathie M.& Wang, Jun& Friedman, Lauren& Vittorino, Roselle& Conley, Lindsay M.& Ho, Lap…[et al.]. Grape-Seed Polyphenolic Extract Improves the Eye Phenotype in a Drosophila Model of Tauopathy. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-482104
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482104