Modified Chitosan-Clay Nanocomposite as a Drug Delivery System Intercalation and In Vitro Release of Ibuprofen
Joint Authors
Abdeen, Rehab
Salahuddin, Nehal
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The present paper focused on the intercalation of ibuprofen into sodium montmorillonite, chitosan, and chitosan montmorillonite nanocomposites as a sustained release drug carrier.
The compounds were characterized by X-ray diffraction (XRD), infrared spectroscopy (IR), thermogravimetric analysis (TGA), and transmission electron microscopy (TEM).
The basal spacing of montmorillonite increased from 9.6 Å to 19.6 Å indicating the intercalation of modified chitosan and ibuprofen between lamellar layers.
UV spectroscopy was employed to monitor the in vitro drug release processes in both pH 5.4 and 7.8 solutions.
The results revealed that ibuprofen was released from MMT, CS, and Mod-CS/MMT steadily and was pH dependent.
American Psychological Association (APA)
Abdeen, Rehab& Salahuddin, Nehal. 2013. Modified Chitosan-Clay Nanocomposite as a Drug Delivery System Intercalation and In Vitro Release of Ibuprofen. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-482106
Modern Language Association (MLA)
Abdeen, Rehab& Salahuddin, Nehal. Modified Chitosan-Clay Nanocomposite as a Drug Delivery System Intercalation and In Vitro Release of Ibuprofen. Journal of Chemistry No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-482106
American Medical Association (AMA)
Abdeen, Rehab& Salahuddin, Nehal. Modified Chitosan-Clay Nanocomposite as a Drug Delivery System Intercalation and In Vitro Release of Ibuprofen. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-482106
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482106
