The Innate Immune System in Alzheimer’s Disease
Joint Authors
Boutajangout, Allal
Wisniewski, Thomas
Source
International Journal of Cell Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is the leading cause for dementia in the world.
It is characterized by two biochemically distinct types of protein aggregates: amyloid β (Aβ) peptide in the forms of parenchymal amyloid plaques and congophilic amyloid angiopathy (CAA) and aggregated tau protein in the form of intraneuronal neurofibrillary tangles (NFT).
Several risk factors have been discovered that are associated with AD.
The most well-known genetic risk factor for late-onset AD is apolipoprotein E4 (ApoE4) (Potter and Wisniewski (2012), and Verghese et al.
(2011)).
Recently, it has been reported by two groups independently that a rare functional variant (R47H) of TREM2 is associated with the late-onset risk of AD.
TREM2 is expressed on myeloid cells including microglia, macrophages, and dendritic cells, as well as osteoclasts.
Microglia are a major part of the innate immune system in the CNS and are also involved in stimulating adaptive immunity.
Microglia express several Toll-like receptors (TLRs) and are the resident macrophages of the central nervous system (CNS).
In this review, we will focus on the recent advances regarding the role of TREM2, as well as the effects of TLRs 4 and 9 on AD.
American Psychological Association (APA)
Boutajangout, Allal& Wisniewski, Thomas. 2013. The Innate Immune System in Alzheimer’s Disease. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-482111
Modern Language Association (MLA)
Boutajangout, Allal& Wisniewski, Thomas. The Innate Immune System in Alzheimer’s Disease. International Journal of Cell Biology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-482111
American Medical Association (AMA)
Boutajangout, Allal& Wisniewski, Thomas. The Innate Immune System in Alzheimer’s Disease. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-482111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482111