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Singular Features of Trypanosomatids' Phosphotransferases Involved in Cell Energy Management
Joint Authors
Miranda, Mariana R.
Pereira, Claudio Alejandro
Cámara, María de los Milagros
Bouvier, León A.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Trypanosomatids are responsible for economically important veterinary affections and severe human diseases.
In Africa, Trypanosoma brucei causes sleeping sickness or African trypanosomiasis, while in America, Trypanosoma cruzi is the etiological agent of Chagas disease.
These parasites have complex life cycles which involve a wide variety of environments with very different compositions, physicochemical properties, and availability of metabolites.
As the environment changes there is a need to maintain the nucleoside homeostasis, requiring a quick and regulated response.
Most of the enzymes required for energy management are phosphotransferases.
These enzymes present a nitrogenous group or a phosphate as acceptors, and the most clear examples are arginine kinase, nucleoside diphosphate kinase, and adenylate kinase.
Trypanosoma and Leishmania have the largest number of phosphotransferase isoforms ever found in a single cell; some of them are absent in mammals, suggesting that these enzymes are required in many cellular compartments associated to different biological processes.
The presence of such number of phosphotransferases support the hypothesis of the existence of an intracellular enzymatic phosphotransfer network that communicates the spatially separated intracellular ATP consumption and production processes.
All these unique features make phosphotransferases a promising start point for rational drug design for the treatment of human trypanosomiasis.
American Psychological Association (APA)
Pereira, Claudio Alejandro& Bouvier, León A.& Cámara, María de los Milagros& Miranda, Mariana R.. 2011. Singular Features of Trypanosomatids' Phosphotransferases Involved in Cell Energy Management. Enzyme Research،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-482125
Modern Language Association (MLA)
Pereira, Claudio Alejandro…[et al.]. Singular Features of Trypanosomatids' Phosphotransferases Involved in Cell Energy Management. Enzyme Research No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-482125
American Medical Association (AMA)
Pereira, Claudio Alejandro& Bouvier, León A.& Cámara, María de los Milagros& Miranda, Mariana R.. Singular Features of Trypanosomatids' Phosphotransferases Involved in Cell Energy Management. Enzyme Research. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-482125
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482125