The Role of Translation Initiation Regulation in Haematopoiesis

Joint Authors

Grech, Godfrey
von Lindern, Marieke

Source

Comparative and Functional Genomics

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-05-09

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Biology

Abstract EN

Organisation of RNAs into functional subgroups that are translated in response to extrinsic and intrinsic factors underlines a relatively unexplored gene expression modulation that drives cell fate in the same manner as regulation of the transcriptome by transcription factors.

Recent studies on the molecular mechanisms of inflammatory responses and haematological disorders indicate clearly that the regulation of mRNA translation at the level of translation initiation, mRNA stability, and protein isoform synthesis is implicated in the tight regulation of gene expression.

This paper outlines how these posttranscriptional control mechanisms, including control at the level of translation initiation factors and the role of RNA binding proteins, affect hematopoiesis.

The clinical relevance of these mechanisms in haematological disorders indicates clearly the potential therapeutic implications and the need of molecular tools that allow measurement at the level of translational control.

Although the importance of miRNAs in translation control is well recognised and studied extensively, this paper will exclude detailed account of this level of control.

American Psychological Association (APA)

Grech, Godfrey& von Lindern, Marieke. 2012. The Role of Translation Initiation Regulation in Haematopoiesis. Comparative and Functional Genomics،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-482130

Modern Language Association (MLA)

Grech, Godfrey& von Lindern, Marieke. The Role of Translation Initiation Regulation in Haematopoiesis. Comparative and Functional Genomics No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-482130

American Medical Association (AMA)

Grech, Godfrey& von Lindern, Marieke. The Role of Translation Initiation Regulation in Haematopoiesis. Comparative and Functional Genomics. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-482130

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-482130