The Role of Translation Initiation Regulation in Haematopoiesis
Joint Authors
Grech, Godfrey
von Lindern, Marieke
Source
Comparative and Functional Genomics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Organisation of RNAs into functional subgroups that are translated in response to extrinsic and intrinsic factors underlines a relatively unexplored gene expression modulation that drives cell fate in the same manner as regulation of the transcriptome by transcription factors.
Recent studies on the molecular mechanisms of inflammatory responses and haematological disorders indicate clearly that the regulation of mRNA translation at the level of translation initiation, mRNA stability, and protein isoform synthesis is implicated in the tight regulation of gene expression.
This paper outlines how these posttranscriptional control mechanisms, including control at the level of translation initiation factors and the role of RNA binding proteins, affect hematopoiesis.
The clinical relevance of these mechanisms in haematological disorders indicates clearly the potential therapeutic implications and the need of molecular tools that allow measurement at the level of translational control.
Although the importance of miRNAs in translation control is well recognised and studied extensively, this paper will exclude detailed account of this level of control.
American Psychological Association (APA)
Grech, Godfrey& von Lindern, Marieke. 2012. The Role of Translation Initiation Regulation in Haematopoiesis. Comparative and Functional Genomics،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-482130
Modern Language Association (MLA)
Grech, Godfrey& von Lindern, Marieke. The Role of Translation Initiation Regulation in Haematopoiesis. Comparative and Functional Genomics No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-482130
American Medical Association (AMA)
Grech, Godfrey& von Lindern, Marieke. The Role of Translation Initiation Regulation in Haematopoiesis. Comparative and Functional Genomics. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-482130
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482130