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Cytotoxic Effects of Bangladeshi Medicinal Plant Extracts
Joint Authors
Grice, I. Darren
Tiralongo, Evelin
Uddin, Shaikh J.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
To investigate the cytotoxic effect of some Bangladeshi medicinal plant extracts, 16 Bangladeshi medicinal plants were successively extracted with n-hexane, dichloromethane, methanol and water.
The methanolic and aqueous extracts were screened for cytotoxic activity against healthy mouse fibroblasts (NIH3T3) and three human cancer-cell lines (gastric: AGS; colon: HT-29; and breast: MDA-MB-435S) using the MTT assay.
Two methanolic extracts (Hygrophila auriculata and Hibiscus tiliaceous) and one aqueous extract (Limnophila indica) showed no toxicity against healthy mouse fibroblasts, but selective cytotoxicity against breast cancer cells (IC50 1.1–1.6 mg mL−1).
Seven methanolic extracts from L.
indica, Clerodendron inerme, Cynometra ramiflora, Xylocarpus moluccensis, Argemone mexicana, Ammannia baccifera and Acrostichum aureum and four aqueous extracts from Hygrophila auriculata, Bruguiera gymnorrhiza, X.
moluccensis and Aegiceras corniculatum showed low toxicity (IC50 > 2.5 mg mL−1) against mouse fibroblasts but selective cytotoxicity (IC50 0.2–2.3 mg mL−1) against different cancer cell lines.
The methanolic extract of Blumea lacera showed the highest cytotoxicity (IC50 0.01–0.08 mg mL−1) against all tested cell lines among all extracts tested in this study.
For some of the plants their traditional use as anticancer treatments correlates with the cytotoxic results, whereas for others so far unknown cytotoxic activities were identified.
American Psychological Association (APA)
Uddin, Shaikh J.& Grice, I. Darren& Tiralongo, Evelin. 2011. Cytotoxic Effects of Bangladeshi Medicinal Plant Extracts. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-482175
Modern Language Association (MLA)
Uddin, Shaikh J.…[et al.]. Cytotoxic Effects of Bangladeshi Medicinal Plant Extracts. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-482175
American Medical Association (AMA)
Uddin, Shaikh J.& Grice, I. Darren& Tiralongo, Evelin. Cytotoxic Effects of Bangladeshi Medicinal Plant Extracts. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-482175
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482175