![](/images/graphics-bg.png)
Can Melatonin Help Us in Radiation Oncology Treatments?
Joint Authors
Aliasgharzadeh, Akbar
Mihandoost, Ehsan
Mahdavi, Seied Rabie
Shirazi, Alireza
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Nowadays, radiotherapy has become an integral part of the treatment regimen in various malignancies for curative or palliative purposes.
Ionizing radiation interacts with biological systems to produce free radicals, which attack various cellular components.
Radioprotectors act as prophylactic agents that are administered to shield normal cells and tissues from the harmful effects of radiation.
Melatonin has been shown to be both a direct free radical scavenger and an indirect antioxidant by stimulating antioxidant enzymes and suppressing prooxidative enzymes activity.
In addition to its antioxidant property, there have also been reports implicating antiapoptotic function for melatonin in normal cells.
Furthermore, through its antitumor and radiosensitizing properties, treatment with melatonin may prevent tumor progression.
Therefore, addition of melatonin to radiation therapy could lower the damage inflicted to the normal tissue, leading to a more efficient tumor control by use of higher doses of irradiation during radiotherapy.
Thus, it seems that, in the future, melatonin may improve the therapeutic gain in radiation oncology treatments.
American Psychological Association (APA)
Mihandoost, Ehsan& Shirazi, Alireza& Mahdavi, Seied Rabie& Aliasgharzadeh, Akbar. 2014. Can Melatonin Help Us in Radiation Oncology Treatments?. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-482180
Modern Language Association (MLA)
Mihandoost, Ehsan…[et al.]. Can Melatonin Help Us in Radiation Oncology Treatments?. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-482180
American Medical Association (AMA)
Mihandoost, Ehsan& Shirazi, Alireza& Mahdavi, Seied Rabie& Aliasgharzadeh, Akbar. Can Melatonin Help Us in Radiation Oncology Treatments?. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-482180
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482180