Interleukin-17 Expression in the Barrett’s Metaplasia-Dysplasia-Adenocarcinoma Sequence
Joint Authors
Bannister, J. R.
Khan, A. L.
Eccleston, D. W.
Hughes, S. F.
Deol-Poonia, R. K.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
This pilot study evaluated the expression of the proinflammatory cytokine IL-17 along the Barrett’s metaplasia-dysplasia-adenocarcinoma sequence by establishing the expression levels of IL-17 in columnar epithelium, intestinal metaplastic cells, and dysplastic/glandular neoplastic cells.
Immunohistochemical techniques were used to examine the accumulation of the proinflammatory cytokine IL-17 in forty (n=40) formalin-fixed, paraffin-embedded oesophageal archived specimens across a range of endoscopic diagnostic categories, and a highly significant difference was found, where P≤0.001, in IL-17 expression (Kruskall Wallis and Mann-Whitney U) between all the cell types examined.
There was also a strong positive correlation (Spearman's rank correlation) between disease progression and IL-17 expression (rs=0.883, P<0.001, n=29), IL-17 expression was absent or absent/weak in columnar epithelium, weak to moderate in columnar metaplastic cells, and moderate to strong in dysplastic/neoplastic cells, which demonstrated that the elevation of IL-17 expression occurs in the progression of the disease.
Understanding the differential expression of IL-17 between benign and malignant tissue potentially has a significant diagnostic, prognostic, and therapeutic value.
Ultimately, this selective biomarker may be employed in routine clinical practice for the screening of oesophageal adenocarcinoma.
American Psychological Association (APA)
Bannister, J. R.& Khan, A. L.& Eccleston, D. W.& Deol-Poonia, R. K.& Hughes, S. F.. 2012. Interleukin-17 Expression in the Barrett’s Metaplasia-Dysplasia-Adenocarcinoma Sequence. ISRN Inflammation،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-482182
Modern Language Association (MLA)
Bannister, J. R.…[et al.]. Interleukin-17 Expression in the Barrett’s Metaplasia-Dysplasia-Adenocarcinoma Sequence. ISRN Inflammation No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-482182
American Medical Association (AMA)
Bannister, J. R.& Khan, A. L.& Eccleston, D. W.& Deol-Poonia, R. K.& Hughes, S. F.. Interleukin-17 Expression in the Barrett’s Metaplasia-Dysplasia-Adenocarcinoma Sequence. ISRN Inflammation. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-482182
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482182