An Aqueous Extract of Radix Astragali, Angelica sinensis, and Panax notoginseng Is Effective in Preventing Diabetic Retinopathy
Joint Authors
Yang, Mingxing
Li, Zhipeng
Yang, Shuyu
Liu, Suhuan
Li, Xiumin
Ou, Zhimin
Xue, Mei
Guo, Yijuan
Li, Xuejun
Liu, Ming
Gao, Dehong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Diabetic retinopathy (DR), in which inflammation has been implicated playing important roles, is one of the most common diabetes complications.
Dang Gui Bu Xue Tang (DBT), an aqueous extract of Radix Astragali and Radix Angelica sinensis, is a classical prescription in Traditional Chinese Medicine for treating inflammation and ischemic diseases.
Here, we investigated the effects of a modified recipe of DBT, with addition of Panax notoginseng, in treating diabetic retinopathy.
An aqueous extract of Radix Astragali, Radix Angelica sinensis, and Panax notoginseng (RRP) was given to Goto-Kakizaki (GK) rats and streptozotocin-induced Sprague-Dawley (SD) rats.
Leukostasis, vascular leakage, and acellular capillaries in retinal vasculature of animals were determined.
Expression of retinal inflammatory biomarkers was assessed.
We found that RRP reduced leukostasis, acellular capillaries, and vascular leakage compared to diabetic control rats.
We also found that RRP decreased the expression of inflammatory factors including IL-1β, IL-6, TNF-α, NF-κB, MCP-1, ICAM-1, or VCAM-1 in the retinas of GK rats and reversed high glucose-induced inhibition of endothelial cell migration and proliferation in vitro.
We conclude that RRP has a potent effect in preventing the pathogenesis and/or progression of DR and thus may serve as a promising nontoxic therapeutic approach of DR.
American Psychological Association (APA)
Gao, Dehong& Guo, Yijuan& Li, Xuejun& Li, Xiumin& Li, Zhipeng& Xue, Mei…[et al.]. 2013. An Aqueous Extract of Radix Astragali, Angelica sinensis, and Panax notoginseng Is Effective in Preventing Diabetic Retinopathy. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-482184
Modern Language Association (MLA)
Gao, Dehong…[et al.]. An Aqueous Extract of Radix Astragali, Angelica sinensis, and Panax notoginseng Is Effective in Preventing Diabetic Retinopathy. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-482184
American Medical Association (AMA)
Gao, Dehong& Guo, Yijuan& Li, Xuejun& Li, Xiumin& Li, Zhipeng& Xue, Mei…[et al.]. An Aqueous Extract of Radix Astragali, Angelica sinensis, and Panax notoginseng Is Effective in Preventing Diabetic Retinopathy. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-482184
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482184