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Daptomycin : Local Application in Implant-Associated Infection and Complicated Osteomyelitis
Joint Authors
Uekoetter, Andreas
Rosslenbroich, Steffen B.
Fuchs, Thomas F.
Reichelt, Rudolf
Tholema-Hans, Nancy
Raschke, Michael J.
Kreis, Carolin
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Background.
The rise of highly resistant bacteria creates a persistent urge to develop new antimicrobial agents.
This paper investigates the application of the lipopeptide antibiotic daptomycin in infections involving the human bone.
Methods.
Compressive and tensile strength testing of daptomycin-laden PMMA was performed referring to the ISO 5833.
The microstructure of the antibiotic-laden PMMA was evaluated by scanning electron microscopy.
Intracellular activity of daptomycin was determined by a human osteoblast infection model.
Elution kinetics of the antibiotic-laden bone cement was measured by using a continuous flow chamber setup.
Results.
There was no significant negative effect of adding 1.225% and 7.5% per weight of daptomycin to the PMMA.
There was no significant difference in intracellular activity comparing gentamicin to daptomycin.
Elution of daptomycin from PMMA showed within the first-hour initial peak values of 15–20 μg/mL.
Conclusion.
Daptomycin has a certain degree of activity in the intracellular environment of osteoblasts.
Daptomycin admixed to PMMA remains bactericidal and does not significantly impair structural characteristics of the PMMA.
The results of this paper suggest that daptomycin might be a potent alternative for treating osteomyelitis and implant-associated infection in trauma and orthopedic surgery caused by multiresistant strains.
American Psychological Association (APA)
Rosslenbroich, Steffen B.& Raschke, Michael J.& Kreis, Carolin& Tholema-Hans, Nancy& Uekoetter, Andreas& Reichelt, Rudolf…[et al.]. 2012. Daptomycin : Local Application in Implant-Associated Infection and Complicated Osteomyelitis. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-482194
Modern Language Association (MLA)
Rosslenbroich, Steffen B.…[et al.]. Daptomycin : Local Application in Implant-Associated Infection and Complicated Osteomyelitis. The Scientific World Journal No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-482194
American Medical Association (AMA)
Rosslenbroich, Steffen B.& Raschke, Michael J.& Kreis, Carolin& Tholema-Hans, Nancy& Uekoetter, Andreas& Reichelt, Rudolf…[et al.]. Daptomycin : Local Application in Implant-Associated Infection and Complicated Osteomyelitis. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-482194
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482194