Central and Peripheral GABAA Receptor Regulation of the Heart Rate Depends on the Conscious State of the Animal
Joint Authors
Bentzen, Bo Hjorth
Grunnet, Morten
Source
Advances in Pharmacological Sciences
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Intuitively one might expect that activation of GABAergic inhibitory neurons results in bradycardia.
In conscious animals the opposite effect is however observed.
GABAergic neurons in nucleus ambiguus hold the ability to control the activity of the parasympathetic vagus nerve that innervates the heart.
Upon GABA activation the vagus nerve will be inhibited leaving less parasympathetic impact on the heart.
The picture is however blurred in the presence of anaesthesia where both the concentration and type of anaesthetics can result in different effects on the cardiovascular system.
This paper reviews cardiovascular outcomes of GABA activation and includes own experiments on anaesthetized animals and isolated hearts.
In conclusion, the impact of changes in GABAergic input is very difficult to predict in these settings, emphasizing the need for experiments performed in conscious animals when aiming at determining the cardiovascular effects of compounds acting on GABAergic neurons.
American Psychological Association (APA)
Bentzen, Bo Hjorth& Grunnet, Morten. 2011. Central and Peripheral GABAA Receptor Regulation of the Heart Rate Depends on the Conscious State of the Animal. Advances in Pharmacological Sciences،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-482198
Modern Language Association (MLA)
Bentzen, Bo Hjorth& Grunnet, Morten. Central and Peripheral GABAA Receptor Regulation of the Heart Rate Depends on the Conscious State of the Animal. Advances in Pharmacological Sciences No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-482198
American Medical Association (AMA)
Bentzen, Bo Hjorth& Grunnet, Morten. Central and Peripheral GABAA Receptor Regulation of the Heart Rate Depends on the Conscious State of the Animal. Advances in Pharmacological Sciences. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-482198
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482198