Blocking Neurogenic Inflammation for the Treatment of Acute Disorders of the Central Nervous System
Joint Authors
Vink, Robert
Turner, Renée Jade
Lewis, Kate Marie
Source
International Journal of Inflammation
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-29
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Classical inflammation is a well-characterized secondary response to many acute disorders of the central nervous system.
However, in recent years, the role of neurogenic inflammation in the pathogenesis of neurological diseases has gained increasing attention, with a particular focus on its effects on modulation of the blood-brain barrier BBB.
The neuropeptide substance P has been shown to increase blood-brain barrier permeability following acute injury to the brain and is associated with marked cerebral edema.
Its release has also been shown to modulate classical inflammation.
Accordingly, blocking substance P NK1 receptors may provide a novel alternative treatment to ameliorate the deleterious effects of neurogenic inflammation in the central nervous system.
The purpose of this paper is to provide an overview of the role of substance P and neurogenic inflammation in acute injury to the central nervous system following traumatic brain injury, spinal cord injury, stroke, and meningitis.
American Psychological Association (APA)
Lewis, Kate Marie& Turner, Renée Jade& Vink, Robert. 2013. Blocking Neurogenic Inflammation for the Treatment of Acute Disorders of the Central Nervous System. International Journal of Inflammation،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-482231
Modern Language Association (MLA)
Lewis, Kate Marie…[et al.]. Blocking Neurogenic Inflammation for the Treatment of Acute Disorders of the Central Nervous System. International Journal of Inflammation No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-482231
American Medical Association (AMA)
Lewis, Kate Marie& Turner, Renée Jade& Vink, Robert. Blocking Neurogenic Inflammation for the Treatment of Acute Disorders of the Central Nervous System. International Journal of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-482231
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482231