Validation of Quetiapine Fumarate in Pharmaceutical Dosage by Reverse-Phase HPLC with Internal Standard Method
Joint Authors
Dubey, Somshankar
Battula, Sreenivas Rao
Venkata, Kiran B.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A rapid, specific, and accurate isocratic HPLC method was developed and validated for the assay of quetiapine fumarate in pharmaceutical dosage forms.
The assay involved an isocratic-elution of quetiapine fumarate in Grace C18 column using mobile-phase composition of 0.1% ortho phosphoric acid with triethyl amine as modifier buffer and acetonitrile in the ratio of 50 : 50 (v/v).The wavelength of detection is 294 nm.
The method showed good linearity in the range of 2.0–50.2 × 10−3 g/Lt.
The runtime of the method is 5 mins.
The developed method was applied to directly and easily analyse of the pharmaceutical tablet preparations.
The percentage recoveries were near 100% for given methods.
The method was completely validated and proven to be rugged.
The excipients did not interfere in the analysis.
The results showed that this method can be used for rapid determination of quetiapine fumarate in pharmaceutical tablet with precision, accuracy, and specificity.
American Psychological Association (APA)
Venkata, Kiran B.& Battula, Sreenivas Rao& Dubey, Somshankar. 2012. Validation of Quetiapine Fumarate in Pharmaceutical Dosage by Reverse-Phase HPLC with Internal Standard Method. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-482233
Modern Language Association (MLA)
Venkata, Kiran B.…[et al.]. Validation of Quetiapine Fumarate in Pharmaceutical Dosage by Reverse-Phase HPLC with Internal Standard Method. Journal of Chemistry No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-482233
American Medical Association (AMA)
Venkata, Kiran B.& Battula, Sreenivas Rao& Dubey, Somshankar. Validation of Quetiapine Fumarate in Pharmaceutical Dosage by Reverse-Phase HPLC with Internal Standard Method. Journal of Chemistry. 2012. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-482233
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482233