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Biological Therapy in Systemic Lupus Erythematosus
Joint Authors
Costallat, Lilian TL
Postal, Mariana
Appenzeller, Simone
Source
International Journal of Rheumatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Systemic lupus erythematosus (SLE) is a prototypic inflammatory autoimmune disorder characterized by multisystem involvement and fluctuating disease activity.
Symptoms range from rather mild manifestations such as rash or arthritis to life-threatening end-organ manifestations.
Despite new and improved therapy having positively impacted the prognosis of SLE, a subgroup of patients do not respond to conventional therapy.
Moreover, the risk of fatal outcomes and the damaging side effects of immunosuppressive therapies in SLE call for an improvement in the current therapeutic management.
New therapeutic approaches are focused on B-cell targets, T-cell downregulation and costimulatory blockade, cytokine inhibition, and the modulation of complement.
Several biological agents have been developed, but this encouraging news is associated with several disappointments in trials and provide a timely moment to reflect on biologic therapy in SLE.
American Psychological Association (APA)
Postal, Mariana& Costallat, Lilian TL& Appenzeller, Simone. 2012. Biological Therapy in Systemic Lupus Erythematosus. International Journal of Rheumatology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-482245
Modern Language Association (MLA)
Postal, Mariana…[et al.]. Biological Therapy in Systemic Lupus Erythematosus. International Journal of Rheumatology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-482245
American Medical Association (AMA)
Postal, Mariana& Costallat, Lilian TL& Appenzeller, Simone. Biological Therapy in Systemic Lupus Erythematosus. International Journal of Rheumatology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-482245
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482245