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Elevated Serum Gamma-Glutamyltransferase Is a Strong Marker of Insulin Resistance in Obese Children
Joint Authors
Lee, Seon Yeong
Sung, Eunju
Chang, Yoosoo
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Elevated levels of serum gamma-glutamyltransferase (GGT) levels have been found to predict the development of type 2 diabetes in adults.
The role of GGT in insulin resistance (IR) among children is largely unknown.
We investigated whether GGT among hepatic enzymes is independently associated with IR in obese Korean children.
A total of 1308 overweight (above the 85th BMI percentile of Korean reference) boys (n=822) and girls (n=486), aged 9–15 years, were studied.
Measures acquired included weight, height, percent body fat (BF%), waist circumference, blood pressure, blood glucose and insulin, C-reactive protein, total cholesterol, triglycerides, HDL-Cholesterol, GGT, aspartate aminotransferase (AST), and alanine aminotransferase (ALT).
IR was calculated using the homeostasis model assessment (HOMA-IR).
Serum GGT and ALT, but not AST, were positively correlated with HOMA-IR in boys (r=0.222 for GGT; P<0.05, r=0.188 for ALT; P<0.05) and girls (r=0.292 for GGT; P<0.05, r=0.258 for ALT; P<0.05).
In multiple regression analysis for HOMA-IR as dependent variable, GGT (β=0.068; P=0.053 in boys, β=0.145; P=0.002 in girls) and ALT (β=0.074; P=0.034 in boys, β=0.130; P=0.005 in girls) emerged as determinants of HOMA-IR after adjusting age, BMI, tanner stage, and triglycerides.
Serum GGT level is a strong marker of IR in obese Korean children.
American Psychological Association (APA)
Lee, Seon Yeong& Sung, Eunju& Chang, Yoosoo. 2013. Elevated Serum Gamma-Glutamyltransferase Is a Strong Marker of Insulin Resistance in Obese Children. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-482253
Modern Language Association (MLA)
Lee, Seon Yeong…[et al.]. Elevated Serum Gamma-Glutamyltransferase Is a Strong Marker of Insulin Resistance in Obese Children. International Journal of Endocrinology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-482253
American Medical Association (AMA)
Lee, Seon Yeong& Sung, Eunju& Chang, Yoosoo. Elevated Serum Gamma-Glutamyltransferase Is a Strong Marker of Insulin Resistance in Obese Children. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-482253
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482253