Impact of Core-Forming Segment Structure on Drug Loading in Biodegradable Polymeric Micelles Using PEG-b-Poly(lactide-co-depsipeptide) Block Copolymers
Joint Authors
Ohya, Yuichi
Kuzuya, Akinori
Takahashi, Akihiro
Ozaki, Yuta
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We synthesized series of amphiphilic AB-type block copolymers having systematic variation in the core-forming segments using poly(lactide-co-depsipeptide)s as a hydrophobic segment and prepared polymeric micelles using the block copolymers, PEG-b-poly(lactide-co-depsipeptide).
We then discussed the relationship between the core-forming segment structure and drug loading efficiency for the polymeric micelles.
PEG-b-poly(lactide-co-depsipeptide)s, PEG-b-PLGL containing l-leucine (Leu), and PEG-b-PLGF containing l-phenylalanine (Phe), with similar molecular weights and various mole fractions of depsipeptide units, were synthesized.
Polymeric micelles entrapping model drug (fluorescein, FL) were prepared using these copolymers.
As a result, PEG-b-poly(lactide-co-depsipeptide) micelles showed higher drug loading compared with PEG-b-PLLA and PEG-b-PDLLA as controls.
The drug loading increased with increase in the mole fraction of depsipeptide unit in the hydrophobic segments.
The introduction of aliphatic and aromatic depsipeptide units was effective to achieve higher FL loading into the micelles.
PEG-b-PLGL micelle showed higher drug loading than PEG-b-PLGF micelle when the amount of FL in feed was high.
These results obtained in this study should be useful for strategic design of polymeric micelle-type drug delivery carrier with high drug loading efficiency.
American Psychological Association (APA)
Takahashi, Akihiro& Ozaki, Yuta& Kuzuya, Akinori& Ohya, Yuichi. 2014. Impact of Core-Forming Segment Structure on Drug Loading in Biodegradable Polymeric Micelles Using PEG-b-Poly(lactide-co-depsipeptide) Block Copolymers. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-482295
Modern Language Association (MLA)
Takahashi, Akihiro…[et al.]. Impact of Core-Forming Segment Structure on Drug Loading in Biodegradable Polymeric Micelles Using PEG-b-Poly(lactide-co-depsipeptide) Block Copolymers. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-482295
American Medical Association (AMA)
Takahashi, Akihiro& Ozaki, Yuta& Kuzuya, Akinori& Ohya, Yuichi. Impact of Core-Forming Segment Structure on Drug Loading in Biodegradable Polymeric Micelles Using PEG-b-Poly(lactide-co-depsipeptide) Block Copolymers. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-482295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482295