EI of the Phosphotransferase System of Escherichia coli : Mathematical Modeling Approach to Analysis of Its Kinetic Properties
Joint Authors
Demin, O. V.
Ma, H.
Karelina, T. A.
Goryanin, I.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-20
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The mathematical model of the operation of the first enzyme of the Escherichia coli phosphotransferase system, EI, is proposed.
Parameters of the kinetic model describing the operation of EI under different conditions are identified on the basis of a large amount of known experimental data.
The verified model is employed to predict modes of operation of EI under both in vivo physiological conditions and in vitro nonphysiological conditions.
The model predicts that under in vivo physiological conditions, the rate of phosphotransfer from EI to the second protein of the phosphotransferase system HPr by the dimer is much higher than by the monomer.
A hypothesis is proposed on the basis of calculations that the transfer by a monomer plays a role in the regulation of chemotaxis.
At submicromolar pyruvate concentration, the model predicts nonmonotonic dependence of the phosphotransfer rate on the substrate (PEP) concentration.
American Psychological Association (APA)
Karelina, T. A.& Ma, H.& Goryanin, I.& Demin, O. V.. 2011. EI of the Phosphotransferase System of Escherichia coli : Mathematical Modeling Approach to Analysis of Its Kinetic Properties. Journal of Biophysics،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-482314
Modern Language Association (MLA)
Karelina, T. A.…[et al.]. EI of the Phosphotransferase System of Escherichia coli : Mathematical Modeling Approach to Analysis of Its Kinetic Properties. Journal of Biophysics No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-482314
American Medical Association (AMA)
Karelina, T. A.& Ma, H.& Goryanin, I.& Demin, O. V.. EI of the Phosphotransferase System of Escherichia coli : Mathematical Modeling Approach to Analysis of Its Kinetic Properties. Journal of Biophysics. 2011. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-482314
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482314