Pharmaceutical Options for Triggering of Final Oocyte Maturation in ART
Joint Authors
Humaidan, Peter
Bernabéu, Rafael
Castillo, Juan Carlos
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Since the pioneering days of in vitro fertilization, hCG has been the gold standard to induce final follicular maturation.
We herein reviewed different pharmaceutical options for triggering of final oocyte maturation in ART.
The new upcoming agent seems to be GnRHa with its potential advantages over hCG trigger.
GnRHa triggering elicits a surge of gonadotropins resembling the natural midcycle surge of gonadotropins, without the prolonged action of hCG, resulting in the retrieval of more mature oocytes and a significant reduction in or elimination of OHSS as compared to hCG triggering.
The induction of final follicular maturation using GnRHa represents a paradigm shift in the ovulation triggering concept in ART and, thus, a way to develop a safer IVF procedure.
Kisspeptins are key central regulators of the neuroendocrine mechanisms of human reproduction, who have been shown to effectively elicit an LH surge and to induce final oocyte maturation in IVF cycles.
This new trigger concept may, therefore, offer a completely new, “natural” pharmacological option for ovulation induction.
Whether kisspeptins will be the future agent to trigger ovulation remains to be further explored.
American Psychological Association (APA)
Castillo, Juan Carlos& Humaidan, Peter& Bernabéu, Rafael. 2014. Pharmaceutical Options for Triggering of Final Oocyte Maturation in ART. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-482369
Modern Language Association (MLA)
Castillo, Juan Carlos…[et al.]. Pharmaceutical Options for Triggering of Final Oocyte Maturation in ART. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-482369
American Medical Association (AMA)
Castillo, Juan Carlos& Humaidan, Peter& Bernabéu, Rafael. Pharmaceutical Options for Triggering of Final Oocyte Maturation in ART. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-482369
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482369