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Estradiol Modulates Membrane-Linked ATPases, Antioxidant Enzymes, Membrane Fluidity, Lipid Peroxidation, and Lipofuscin in Aged Rat Liver
Joint Authors
Kumar, Pardeep
Kale, R. K.
Baquer, Najma Zaheer
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Free radical production and oxidative stress are known to increase in liver during aging, and may contribute to the oxidative damage.
These changes increase during menopausal condition in females when the level of estradiol is decreased.
The objective of this study was to observe the changes in activities of membrane linked ATPases (Na+K+ ATPase, Ca2+ ATPase), antioxidant enzymes (superoxide dismutase, glutathione-S-transferase), lipid peroxidation levels, lipofuscin content and membrane fluidity occurring in livers of female rats of 3, 12 and 24 months age groups, and to see whether these changes are restored to 3 months control levels rats after exogenous administration of 17-β-estradiol (E2).
The aged rats (12 and 24 months) were given subcutaneous injection of E2 (0.1 μg/g body weight) daily for one month.
The results obtained in the present work revealed that normal aging was associated with significant decrease in the activities of membrane linked ATPases, antioxidant enzymes, membrane fluidity and an increase in lipid peroxidation and lipofuscin content in livers of aging female rats.
The present study showed that E2 treatment reversed the changes to normal levels.
E2 treatment may be beneficial in preventing some of the age related changes in the liver by increasing antioxidant defenses.
American Psychological Association (APA)
Kumar, Pardeep& Kale, R. K.& Baquer, Najma Zaheer. 2011. Estradiol Modulates Membrane-Linked ATPases, Antioxidant Enzymes, Membrane Fluidity, Lipid Peroxidation, and Lipofuscin in Aged Rat Liver. Journal of Aging Research،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-482375
Modern Language Association (MLA)
Kumar, Pardeep…[et al.]. Estradiol Modulates Membrane-Linked ATPases, Antioxidant Enzymes, Membrane Fluidity, Lipid Peroxidation, and Lipofuscin in Aged Rat Liver. Journal of Aging Research No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-482375
American Medical Association (AMA)
Kumar, Pardeep& Kale, R. K.& Baquer, Najma Zaheer. Estradiol Modulates Membrane-Linked ATPases, Antioxidant Enzymes, Membrane Fluidity, Lipid Peroxidation, and Lipofuscin in Aged Rat Liver. Journal of Aging Research. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-482375
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482375