Epigenetics in Prostate Cancer
Joint Authors
Albany, Costantine
Yellapragada, Sarvari
Hahn, Noah M.
Aparicio, Ana M.
Alva, Ajjai S.
Singal, Rakesh
Sonpavde, Guru
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Prostate cancer (PC) is the most commonly diagnosed nonskin malignancy and the second most common cause of cancer death among men in the United States.
Epigenetics is the study of heritable changes in gene expression caused by mechanisms other than changes in the underlying DNA sequences.
Two common epigenetic mechanisms, DNA methylation and histone modification, have demonstrated critical roles in prostate cancer growth and metastasis.
DNA hypermethylation of cytosine-guanine (CpG) rich sequence islands within gene promoter regions is widespread during neoplastic transformation of prostate cells, suggesting that treatment-induced restoration of a “normal” epigenome could be clinically beneficial.
Histone modification leads to altered tumor gene function by changing chromosome structure and the level of gene transcription.
The reversibility of epigenetic aberrations and restoration of tumor suppression gene function have made them attractive targets for prostate cancer treatment with modulators that demethylate DNA and inhibit histone deacetylases.
American Psychological Association (APA)
Albany, Costantine& Alva, Ajjai S.& Aparicio, Ana M.& Singal, Rakesh& Yellapragada, Sarvari& Sonpavde, Guru…[et al.]. 2011. Epigenetics in Prostate Cancer. Prostate Cancer،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-482383
Modern Language Association (MLA)
Albany, Costantine…[et al.]. Epigenetics in Prostate Cancer. Prostate Cancer No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-482383
American Medical Association (AMA)
Albany, Costantine& Alva, Ajjai S.& Aparicio, Ana M.& Singal, Rakesh& Yellapragada, Sarvari& Sonpavde, Guru…[et al.]. Epigenetics in Prostate Cancer. Prostate Cancer. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-482383
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482383